4 products were found matching "1217486-61-7"!
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BYL719
Item number: Cay16986-5
BYL719 is an inhibitor of phosphoinositide 3-kinase alpha (PI3Kalpha, IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kalpha over PI3Kbeta, PI3Kdelta, PI3Kgamma, and PI4Kbeta (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34,...
| Keywords: | Alpelisib, NVP-BYL719,... |
| Application: | PI3Kalpha inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441.5 D |
From 73.00€
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Alpelisib, Free Base (BYL-719, CAS 1217486-61-7), >99%
Item number: LC-A-4477_10mg
Soluble in DMSO
| Keywords: | Alpelisib, NVP-BYL719,... |
| Application: | PI3Kalpha inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441,47 D |
From 106.00€
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BYL719
Item number: LKT-B9700.1
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway.
| Keywords: | BYL-719 |
| Application: | PI3K inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441.47 D |
From 83.00€
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Alpelisib
Item number: SYN-1230-M001
Solid. Soluble in DMSO or DMF. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study,...
| Keywords: | (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, BYL719,... |
| Application: | Selective PI3K alpha inhibitor |
| CAS | 1217486-61-7 |
| MW: | 441,5 D |
From 106.00€
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