Alpelisib

Item number	Size	Manual	SDS	Delivery time	Price
SYN-1230-M001	1 mg	-	-	3 - 9 business days*	106.00€
SYN-1230-M005	5 mg	-	-	3 - 9 business days*	198.00€
SYN-1230-M010	10 mg	-	-	3 - 9 business days*	289.00€
SYN-1230-M050	50 mg	-	-	3 - 9 business days*	988.00€
SYN-1230-M100	100 mg	-	-	3 - 9 business days*	-

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Solid. Soluble in DMSO or DMF. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect... more

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Product information "Alpelisib"

Solid. Soluble in DMSO or DMF. Selective PI3Kalpha inhibitor with IC50 of 5nM. Has minimal effect on other PI3K isoforms. Exhibits favorable pharmacokinetics and excellent oral bioavailability in animal models. In xenografts using nude mice, it showed dose-dependent effects of tumour inhibition. In a phase Ib study, it showed synergistic anti-tumor activity with endocrine therapy against ER+/PIK3CA mutated breast cancer cells.

Keywords:	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, BYL719, NVP-BYL719
Supplier:	SYNkinase
Supplier-Nr:	1230

Properties

Application:	Selective PI3K alpha inhibitor
MW:	441,5 D
Formula:	C19H22F3N5O2S
Purity:	>95%
Format:	Solid

Database Information

CAS :	1217486-61-7\| Matching products
KEGG ID :	K00922 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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