Akt Inhibitor XI

The kinase Akt (also known as protein kinase B or PKB) modulates cell proliferation, metabolism, and survival, as well as angiogenesis. Akt inhibitor XI is a cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 µM). It also causes NF-kappaB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells. Molecular modeling indicates that this inhibitor interacts with the pleckstrin homology and kinase domains of Akt. Akt inhibitor XI is commonly used in the range of 1-20 µM to assess the role of Akt in cellular responses.Formal Name: (SP-4-3)-dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-kappaN2,kappaS]-copper. CAS Number: 902779-59-3. Synonyms: FPA-124. Molecular Formula: C11H9Cl2CuN3O2S. Formula Weight: 381.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml. lambdamax: 273, 308 nm. SMILES: O=C1C2=CC=CC=C2OC=C1/C=[N](NC(N)=[S]3)\[Cu+2]3([Cl-])[Cl-]. InChi Code: InChI=1S/C11H9N3O2S.2ClH.Cu/c12-11(17)14-13-5-7-6-16-9-4-2-1-3-8(9)10(7)15,,,/h1-6H,(H3,12,14,17),2*1H,/q,,,+2/p-2/b13-5+,,,. InChi Key: HZRXQEVFXXQYFS-VBPDOGLUSA-L.