AG-528
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
AG-528 is a tyrphostin that inhibits EGFR and HER2 (IC50s = 12 and 4.9 µM, respectively, for... more
Product information "AG-528"
AG-528 is a tyrphostin that inhibits EGFR and HER2 (IC50s = 12 and 4.9 µM, respectively, for inhibition of autophosphorylation). It also inhibits pantothenate kinase 3 (PanK3, IC50 = 3 µM). AG-528 inhibits EGF-dependent proliferation of HER14 cells (IC50 = 25 µM).Formal Name: alphaE-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-beta-oxo-1H-indole-1-propanenitrile. CAS Number: 133550-49-9. Synonyms: Tyrphostin AG-528. Molecular Formula: C18H14N2O3. Formula Weight: 306.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 248, 363 nm. SMILES: O=C(/C(C#N)=C/C1=CC(O)=C(O)C=C1)N2CCC3=CC=CC=C32. InChi Code: InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+. InChi Key: MYKCTDWWIWGLHW-NTEUORMPSA-N.
| Keywords: | Tyrphostin AG-528, alphaE-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-beta-oxo-1H-indole-1-propanenitrile |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 29666 |
Properties
| Application: | Tyrphostin, EGFR / HER2 inhibitor |
| MW: | 306.3 D |
| Formula: | C18H14N2O3 |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 133550-49-9| Matching products |
| KEGG ID : | K04361 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H371, H373 |
| P Phrases: | P260, P264, P270, P314, P308+P311, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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