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Item number: Cay29666-10

AG-528 is a tyrphostin that inhibits EGFR and HER2 (IC50s = 12 and 4.9 µM, respectively, for inhibition of autophosphorylation). It also inhibits pantothenate kinase 3 (PanK3, IC50 = 3 µM). AG-528 inhibits EGF-dependent proliferation of HER14 cells (IC50 = 25 µM).Formal Name:...

Keywords:	Tyrphostin AG-528, alphaE-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-beta-oxo-1H-indole-1-propanenitrile
Application:	Tyrphostin, EGFR / HER2 inhibitor
CAS	133550-49-9
MW:	306.3 D

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Tyrphostin AG 528

Item number: TGM-T4528-100mg

Description: Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 µM) and ErbB2 (IC50: 2.1 µM). Target: EGFR. Smiles: Oc1ccc(\C=C(\C#N)C(=O)N2CCc3ccccc23)cc1O. References: Zhu, N., Tran, P., Bell, N. et al. J Chem Crystallogr (2007) 37: 679. https://doi.org/10.1007/s10870-007-9231-8

Keywords:	Tyrphostin B66 , AG 528
Application:	Tyrphostin, EGFR / HER2 inhibitor
CAS	133550-49-9
MW:	306.32 D

From 38.00€ *

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