AG-112

An EGFR inhibitor, inhibits EGFR-catalyzed phosphorylation of poly(GAT) in a cell-free assay (IC50 = 0.125 µM), inhibits calcineurin phosphatase activity in a cell-free assay (IC50 = 30 µM), inhibits diabetes-induced growth of VSMCs isolated from type 2 diabetic rats, reduces diabetes-induced increases in superoxide generation and NADPH oxidase activity in the same cells. SMILES: N#C/C(C#N)=C(C(C#N)=CC1=CC=C(C=C1)O)\N. InChi Code: InChI=1S/C13H8N4O/c14-6-10(13(17)11(7-15)8-16)5-9-1-3-12(18)4-2-9/h1-5,18H,17H2. InChi Key: DXVJRTIPBNBLLB-UHFFFAOYSA-N