Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11501-1 1 mg -

5 - 10 business days*

Cay11501-5 5 mg -

5 - 10 business days*

Cay11501-10 10 mg -

5 - 10 business days*

Cay11501-25 25 mg -

5 - 10 business days*

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis.... more
Product information "ABT-737"
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, leading to apoptosis. ABT-737, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It shows synergy with diverse therapeutics and radiation to trigger apoptosis in cancer cells and xenografts.
Keywords: 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 11501


Application: Potent, cell-permeable BH3 domain mimetic
MW: 813.4 D
Formula: C42H45ClN6O5S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 852808-04-9| Find alternatives
KEGG ID : K02161 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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