Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11501-1 1 mg -

6 - 10 business days*

Cay11501-5 5 mg -

6 - 10 business days*

Cay11501-10 10 mg -

6 - 10 business days*

Cay11501-25 25 mg -

6 - 10 business days*

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis.... more
Product information "ABT-737"
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki death proteins, leading to apoptosis. ABT-737, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It shows synergy with diverse therapeutics and radiation to trigger apoptosis in cancer cells and xenografts. Formal Name: 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide. CAS Number: 852808-04-9. Molecular Formula: C42H45ClN6O5S2. Formula Weight: 813.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 5 mg/ml. lambdamax: 251, 311, 409 nm. SMILES: O=C(NS(C1=CC([N+]([O-])=O)=C(N[C@H](CCN(C)C)CSC2=CC=CC=C2)C=C1)(=O)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)C=CC=C5)CC4)C=C3. InChi Code: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t3. InChi Key: HPLNQCPCUACXLM-PGUFJCEWSA-N.
Keywords: 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 11501


Application: Potent, cell-permeable BH3 domain mimetic
MW: 813.4 D
Formula: C42H45ClN6O5S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 852808-04-9| Matching products
KEGG ID : K02161 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Our products are for laboratory research use only: Not for administration to humans!
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