ABT-239

ABT-239 is a histamine H3 receptor antagonist (Kis = 0.316 and 1.258 nM, respectively, for the human and rat receptors). In vivo, ABT-239 (0.1-1 mg/kg) inhibits the dipsogenic response induced by (R)-(-)-alpha-methylhistamine (Cay25601) in mice. It improves social memory in adult and aged rats and attenuates methamphetamine-induced hyperactivity in mice. ABT-239 (3 mg/kg) decreases escape latency in the Morris water maze in a rat model of chronic stress. SMILES: N#CC1=CC=C(C2=CC=C3OC(CCN4CCC[C@H]4C)=CC3=C2)C=C1. InChi Code: InChI=1S/C22H22N2O/c1-16-3-2-11-24(16)12-10-21-14-20-13-19(8-9-22(20)25-21)18-6-4-17(15-23)5-7-18/h4-9,13-14,16H,2-3,10-12H2,1H3/t16-/m1/s1. InChi Key: KFHYZKCRXNRKRC-MRXNPFEDSA-N