AB-MECA

AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells). It inhibits LPS-induced TNF-alpha production in primary cultured human lung macrophages (pD2 = 6.9). AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 µM and increases bronchoconstriction in vivo when administered at a dose of 3 µg/kg in a guinea pig model of ovalbumin-sensitized asthma. A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).Formal Name: 1-[6-[[(4-aminophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-beta-D-ribofuranuronamide. CAS Number: 152918-26-8. Molecular Formula: C18H21N7O4. Formula Weight: 399.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 269 nm. SMILES: [H][C@]1(O[C@H](C(NC)=O)[C@@H](O)[C@H]1O)N2C=NC3=C(NCC4=CC=C(N)C=C4)N=CN=C32. InChi Code: InChI=1S/C18H21N7O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-2-4-10(19)5-3-9/h2-5,7-8,12-14,18,26-27H,6,19H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1. InChi Key: LDYMCRRFCMRFKB-MOROJQBDSA-N.