46 products were found matching "K04268"!

DPTN is an adenosine A3 receptor antagonist (Ki = 0.36 nM for the human receptor). It is selective for the adenosine A3 receptor over the adenosine A1 and A2A receptors (Kis = >666 and >826 nM, respectively). DPTN (10 mg/kg) prevents dye leakage in a rat model of plasma extravasation induced by the adenosine A3...

Description: AB-MECA is a high-affinity A3 adenosine receptor agonist with significant affinity for recombinant A1 and A3 receptors. Target: Others. Smiles: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3ccc(N)cc3)ncnc12. References: Shearman LP, et al. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine...

Description: LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). Target: Others. Smiles: Clc1ccc(Nc2nc3ccccc3c3nc([nH]c23)C2CCCCC2)cc1Cl. References: Gao ZG, Verzijl D, Zweemer A et al. Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by...

Description: MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 receptor antagonist Ki: 18.9 nM and 113 nM for human and rat A3 receptors, respectively)....

Description: HEMADO is a potent and selective agonist of the adenosine A3 receptor [Ki: 1.1 nM at the human A3 subtype]. Target: Others. Smiles: O[C@H]1[C@H](N2C=3C(N=C2)=C(NC)N=C(C#CCCCC)N3)O[C@H](CO)[C@H]1O. References: Klotz KN, et al. [3H]HEMADO- a novel tritiated agonist selective for the human adenosine A3...

Description: The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep...

Description: Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist. Target: Adenosine Receptor. Smiles: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12. References: Schaick E A V , Jacobson K A , Kim H O , et al. Hemodynamic effects and histamine release elicited by the selective...

Description: Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 µM), induces robust anti-inflammatory effect in psoriasis patients. Target: Adenosine Receptor, Apoptosis. Smiles: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12. References: Cohen S , Barer F ,...

Description: Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM). Target: Aurora Kinase, Adenosine Receptor, Autophagy. Smiles: C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2[nH]cnc12. References: Chen S, et al. J Am Chem Soc. 2004, 126(2),...

MRS1220 is an adenosine A3 receptor antagonist (Ki = 0.65 nM for the human receptor). It is selective for human adenosine A3 receptors over rat adenosine A1 and A2receptors (Kis = 305 and 52 nM, respectively). MRS1220 inhibits [35S]GTPgammaS binding in HEK293 cells expressing human adenosine A3 receptors (IC50 = 7.2...

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher...

MRS1523 is an adenosine A3 receptor antagonist. It binds to the human adenosine A3 receptor (Ki = 0.0189 µM), as well as selectively binds rat adenosine A3 over A1 and A2A receptors (Kis = 0.113, 15.6, and 2.05 µM, respectively) in radioligand binding assays. It inhibits the proliferation of B16-BL6 mouse melanoma...