49 products were found matching "K04268"!

Recombinant CHO-K1 cells stably overexpress human adenosine A3 receptor (ADORA3) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

A precursor in the synthesis of adenosine A3 receptor antagonists with anticancer activity in vitro. Formulation: A solid. InChI: InChI=1S/C5H6N4/c1-9-3-4(2-6)5(7)8-9/h3H,1H3,(H2,7,8). InChIKey: FBQOIRKIQMQJNS-UHFFFAOYSA-N. SMILES: CN1N=C(N)C(C#N)=C1

An adenosine A3 receptor antagonist (Ki = 0.8 nM for the human receptor), selective for the adenosine A3 receptor over adenosine A1, -A2A, and -A2B receptors (Kis = 1,197, 140, and 2,056 nM, respectively, for the human receptors), inhibits IB-MECA-induced cAMP accumulation in CHO cells expressing the human adenosine...

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher...

MRS1523 is an adenosine A3 receptor antagonist. It binds to the human adenosine A3 receptor (Ki = 0.0189 µM), as well as selectively binds rat adenosine A3 over A1 and A2A receptors (Kis = 0.113, 15.6, and 2.05 µM, respectively) in radioligand binding assays. It inhibits the proliferation of B16-BL6 mouse melanoma...

CGS 15943 is an orally bioavailable non-xanthine antagonist at adenosine (A) receptors with IC50 values of 3.5, 4.2, 16, and 51 nM in CHO cells transfected with human recombinant A1, A2A, A2B, and A3 receptors, respectively. It also binds to the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110gamma, and...

HEMADO is a selective agonist of the adenosine A3 receptor (Kis = 1.1, 327, and 1,230 nM for A3, A1, and A2A receptors, respectively). HEMADO reduces release of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) from myocardium in isolated rat hearts subjected to ischemia-reperfusion injury.Formal Name:...

2-Cl-IB-MECA is an adenosine A3 receptor agonist. It binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity with an IC50 value of 66.8 nM in CHO cell membranes expressing rat A3 receptors. 2-Cl-IB-MECA (10 and...

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine (Cay-21232) in isolated porcine coronary artery...

2-Cl-IB-MECA acts as an A3 adenosine receptor-selective nucleoside. Solubility: >20 mg/ml in DMSO.

The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation. A3 AR...

Adenosine is a purine nucleoside composed of adenine and ribose linked by a glycosidic linkage. It is an endogenous ligand of a family of four adenosine receptors, which serve diverse roles related to smooth muscle tone, central nervous system regulation, and cardiac function. Adenosine is a precursor for adenosine...