A-366
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: A-366 is a highly selective peptide-competitive histone methyltransferase G9a... more
Product information "A-366"
Description: A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM, and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1. References: Pappano WN, et al. PLoS One. 2015, 10(7):e0131716.
| Keywords: | A366, A 366 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3624 |
Properties
| Application: | EHMT2 inhibitor |
| MW: | 329.44 D |
| Formula: | C19H27N3O2 |
Database Information
| CAS : | 1527503-11-2| Matching products |
| KEGG ID : | K11420 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H410 |
| P Phrases: | P273, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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