A-1155463

A-1155463 is an inhibitor of Bcl-xL (Ki = is = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected cells (EC50 = <10 nM).Formal Name: 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid. CAS Number: 1235034-55-5. Molecular Formula: C35H32FN5O4S2. Formula Weight: 669.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 252, 292 nm. SMILES: CN(C)CC#CC1=CC=C(OCCCC2=C(C(O)=O)N=C(N3CC(C(C(NC4=NC5=C(C=CC=C5)S4)=O)=CC=C6)=C6CC3)S2)C(F)=C1. InChi Code: InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42). InChi Key: SOYCFODXNRVBTI-UHFFFAOYSA-N.