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A-1155463
Item number: TGM-T6748-10mg
Description: A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). Target: BCL. Smiles:...
| Keywords: | A1155463, A 1155463 |
| Application: | Bcl-xL inhibitor |
| CAS | 1235034-55-5 |
| MW: | 669.79 D |
From 40.00€
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A-1155463
Item number: Cay27369-1
A-1155463 is an inhibitor of Bcl-xL (Ki = is = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected...
| Keywords: | 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluoro... |
| Application: | Bcl-xL inhibitor |
| CAS | 1235034-55-5 |
| MW: | 669.8 D |
From 49.00€
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