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Item number: Cay11046-1
2-NBDG is a fluorescent derivative of glucose whose uptake is competitively inhibited by D-glucose (Cay-23733), but not L-glucose (Cay-20829) or sucrose, in E. coli. It has been used to monitor glucose uptake by bacteria and live mammalian cells and in tumor biopsies. 2-NBDG displays excitation/emission maxima of...
Keywords: | NBD-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose |
Application: | Deoxyglucose analog |
CAS | 186689-07-6 |
MW: | 342.3 D |
From 49.00€
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Item number: Cay12018-25
Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...
Keywords: | 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid |
Application: | Autotaxin Inhibitor |
CAS | 1144035-53-9 |
MW: | 478.3 D |
From 65.00€
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Item number: Cay13122-1
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...
Keywords: | CT 99021,... |
Application: | GSK3alpha and GSK3beta inhibitor |
CAS | 252917-06-9 |
MW: | 465.3 D |
From 43.00€
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Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
Keywords: | gamma-Secretase Inhibitor XXI,... |
Application: | gamma-Secretase inhibitor |
CAS | 209986-17-4 |
MW: | 490.5 D |
From 254.00€
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Item number: Cay71210-100
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
Keywords: | Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester |
Application: | HIF-PH inhibitor |
CAS | 89464-63-1 |
MW: | 175.1 D |
From 26.00€
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Item number: Cay71820-1
Calcitriol is a vitamin D3 receptor agonist and active metabolite of vitamin D3 (Cay-11792). It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy vitamin D3 (Cay-9000683) in the liver, followed by further hydroxylation at the 1alpha-position in the kidney. Calcitriol binds...
Keywords: | 1alpha,25-dihydroxy Vitamin D3, 9,10-secocholesta-5Z,7E,10(19)-triene-1alpha,3beta,25-triol |
Application: | Metabolic studies |
CAS | 32222-06-3 |
MW: | 416.6 D |
From 114.00€
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Item number: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
Keywords: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
Application: | PKC activator |
CAS | 16561-29-8 |
MW: | 616.8 D |
From 50.00€
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Item number: Cay10012628-5
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle...
Keywords: | Z-Leu-Leu-Leu-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
Application: | Proteasome inhibitor |
CAS | 133407-82-6 |
MW: | 475.6 D |
From 27.00€
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Item number: Cay10522-1
Thapsigargin is an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50 = ~30 nM for the rat liver microsomal enzyme), an ER stress inducer, and a sesquiterpene lactone that has been found in Thapsia. It increases intracellular calcium levels in isolated rat hepatocytes (EC50 = ~80 nM) and...
Keywords: | (3S,3aS,4R,6R,7S,8R)-6-acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a... |
Application: | SERCA inhibitor |
CAS | 67526-95-8 |
MW: | 650.8 D |
From 94.00€
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Item number: Cay21129-1
Altertoxin I is a natural mycotoxin first isolated from fungi of the genus Alternaria. It is a hydroxyperylenequinone that shows mutagenic activity against S. typhimurium and inhibits human topoisomerase II and bacterial gyrase. Altertoxin I completely inhibits replication of HIV-1 virus at 2.2 µM in a cell-based...
Keywords: | Dihydroalterperylenol, (1S,12aR,12bS)-1,2,11,12,12a,12b-hexahydro-1,4,9,12a-tetrahydroxy-3,10-perylenedione |
Application: | Mycotoxin |
CAS | 56258-32-3 |
MW: | 352.3 D |
From 425.00€
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Item number: Cay71740-10
Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...
Keywords: | BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
Application: | PPARgamma agonist |
CAS | 122320-73-4 |
MW: | 357.4 D |
From 43.00€
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Item number: Cay11315-5
Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in...
Keywords: | Aburamycin B, CMA3, NSC 58514,... |
Application: | FC, GC base pair fluorescent probe |
CAS | 7059-24-7 |
MW: | 1183.3 D |
From 68.00€
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