Biochemicals

In this category you’ll find an extensive portfolio of biochemicals: inhibitors, ligands and substrates of various enzymes and receptors, regulatory compounds, assay components and dyes. Besides that it includes carbohydrates, amino acids, antioxidants and a wide array of other products and reagents for biochemical research.

In this category you’ll find an extensive portfolio of biochemicals: inhibitors, ligands and substrates of various enzymes and receptors, regulatory compounds, assay components and dyes. Besides... read more »
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Biochemicals

In this category you’ll find an extensive portfolio of biochemicals: inhibitors, ligands and substrates of various enzymes and receptors, regulatory compounds, assay components and dyes. Besides that it includes carbohydrates, amino acids, antioxidants and a wide array of other products and reagents for biochemical research.

2 from 1410 pages
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FCCP
FCCP

Item number: Cay15218-10

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 µM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the...
Keywords: Trifluoromethoxy carbonylcyanide phenylhydrazone, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile
Application: Inhibits mitochondrial oxidative phosphorylation, Uncoupling reagent
CAS 370-86-5
MW: 254.2 D
From 74.00€ *
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L-NIL (hydrochloride)
L-NIL (hydrochloride)

Item number: Cay80310-10

L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection...
Keywords: N6-(1-iminoethyl)-L-lysine, dihydrochloride
Application: INOS inhibitor
CAS 159190-45-1
MW: 260.2 D
From 12.00€ *
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Nitisinone
Nitisinone

Item number: LKT-N3476.50

Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Keywords: NTBC, orfadin
Application: 4-hydroxyphenylpyruvate dioxygenase inhibitor
CAS 104206-65-7
MW: 329.23 D
From 63.00€ *
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2-NBDG
2-NBDG

Item number: Cay11046-1

2-NBDG is a fluorescent derivative of glucose whose uptake is competitively inhibited by D-glucose (Cay-23733), but not L-glucose (Cay-20829) or sucrose, in E. coli. It has been used to monitor glucose uptake by bacteria and live mammalian cells and in tumor biopsies. 2-NBDG displays excitation/emission maxima of...
Keywords: NBD-Glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose
Application: Deoxyglucose analog
CAS 186689-07-6
MW: 342.3 D
From 44.00€ *
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CHIR99021
CHIR99021

Item number: Cay13122-10

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein...
Keywords: CT 99021,...
Application: GSK3alpha and GSK3beta inhibitor
CAS 252917-06-9
MW: 465.3 D
From 32.00€ *
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DMOG
DMOG

Item number: Cay71210-100

The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
Keywords: Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester
Application: HIF-PH inhibitor
CAS 89464-63-1
MW: 175.1 D
From 18.00€ *
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Calcitriol
Calcitriol

Item number: Cay71820-1

Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D3, the principal circulating form of vitamin D. A second, tightly regulated...
Keywords: 1alpha,25-dihydroxy Vitamin D3, 9,10-secocholesta-5Z,7E,10(19)-triene-1alpha,3beta,25-triol
Application: Metabolic studies
CAS 32222-06-3
MW: 416.6 D
From 85.00€ *
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Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate

Item number: Cay10008014-1

Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
Keywords: 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,...
Application: PKC activator
CAS 16561-29-8
MW: 616.8 D
From 37.00€ *
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(S)-MG132
(S)-MG132

Item number: Cay10012628-5

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle...
Keywords: Z-Leu-Leu-Leu-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Application: Proteasome inhibitor
CAS 133407-82-6
MW: 475.6 D
From 19.00€ *
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S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

Item number: Cay13956-2500

S-(5'-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine (Cay-13603). SAM is also metabolized...
Keywords: AdoMet, SAM, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine, dihydrochloride
Application: Methyl donor
CAS 86867-01-8
MW: 507.8 D
From 42.00€ *
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Rosiglitazone
Rosiglitazone

Item number: Cay71740-10

Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Keywords: BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Application: PPARgamma agonist
CAS 122320-73-4
MW: 357.4 D
From 35.00€ *
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Compound E
Compound E

Item number: Cay15579-1

gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
Keywords: gamma-Secretase Inhibitor XXI,...
Application: Gamma-Secretase inhibitor
CAS 209986-17-4
MW: 490.5 D
From 194.00€ *
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2 from 1410 pages