8-M-PDOT

8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 µg/µl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson's disease.Formal Name: N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-propanamide. CAS Number: 134865-70-6. Synonyms: AH 002. Molecular Formula: C14H19NO2. Formula Weight: 233.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. SMILES: COC1=CC=CC2=C1CC(NC(CC)=O)CC2. InChi Code: InChI=1S/C14H19NO2/c1-3-14(16)15-11-8-7-10-5-4-6-13(17-2)12(10)9-11/h4-6,11H,3,7-9H2,1-2H3,(H,15,16). InChi Key: RVIGBTUDFAGRTQ-UHFFFAOYSA-N.