39 products were found matching "K04286"!

Description: Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1. Target: Melatonin...

Description: Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits...

Description: DH-97 is a potent MT2 melatonin receptor antagonist (pKi value = 8.03). Target: Others. Smiles: C(C=1N(C(CCCC)=O)C=2C(C1CCN)=CC=CC2)C3=CC=CC=C3

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine, Cay-14427) that binds the melatonin MT2 receptor (Ki = 41 nM). It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina. N-acetyl Tryptamine is also a reaction product of...

6-hydroxy Melatonin is an active metabolite of melatonin (Cay-14427). It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC50 =...

Ramelteon is a melatonin (MT) receptor agonist (Kis = 14, 112, and 23.1 pM for human MT1, human MT2, and chick forebrain receptors, respectively). It is selective for MT1 and MT2 over MT3 receptors (Ki = 2.65 µM for hamster brain MT3 receptors) as well as a panel of benzodiazepine, dopamine, and opiate receptors,...

Agomelatine is an agonist of melatonin (MT) receptors and a derivative of melatonin (Cay-14427). It binds to MT1 and MT2 receptors (Kis = 0.14 and 0.41 nM, respectively) and has an EC50 value of 0.1 nM in a [35S]GTPgammaS binding assay using CHO cells expressing MT2 receptors. Agomelatine is also an antagonist of...

Melatonin analog, MT1/2 agonist.

Protein function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. [The UniProt Consortium]

2-iodomelatonin is a potent agonist of melatonin receptor 1 (MT1, Ki = 28 pM) that is 5-fold selective for MT1 over MT2. It inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 30-fold more potently than melatonin (Cay-14427) with an EC50 value of 11 pM. 2-iodomelatonin has been used to...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: MEL-1B-R, MT2, MTNR1B Protein function: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by...