8-Chloroadenosine

8-Chloroadenosine is a nucleoside analog and an active metabolite of the anticancer agent 8-chloro cAMP. It is formed from 8-chloro cAMP by phosphodiesterases (PDEs) and upon entry into cells, 8-chloroadenosine is phosphorylated by adenosine kinase to produce 8-chloro-ATP. 8-Chloroadenosine (10 µM) inhibits RNA, but not DNA, synthesis in vitro. It is cytotoxic to patient-derived multiple myeloma cells in a concentration-dependent manner. 8-chloroadenosine (50 mg/kg) reduces tumor growth by 50% in an HCT116 colorectal cancer mouse xenograft model.Formal Name: 8-chloro-adenosine. CAS Number: 34408-14-5. Molecular Formula: C10H12ClN5O4. Formula Weight: 301.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble. lambdamax: 262 nm. SMILES: ClC(N([C@]1([H])O[C@@H]([C@H]([C@H]1O)O)CO)C2=NC=N3)=NC2=C3N. InChi Code: InChI=1S/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)/t3-,5-,6-,9-/m1/s1. InChi Key: MHDPPLULTMGBSI-UUOKFMHZSA-N.