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7-Aminocephalosporanic acid (7-ACA) is a building block of cephalosporin antibiotics, including cephalosporin C (Cay-33262) and cefapirin (Cay-17406). It binds to heat shock protein 90beta (Hsp90beta, Kd = 6.201 µM) and inhibits sterol regulatory element binding protein (SREBP) activation in a reporter assay using Hl 7702 cells when used at a concentration of 40 µM. 7-ACA (40 µM) inhibits increases in total cholesterol and triglyceride levels induced by palmitic acid (Cay-10006627) and oleic acid (Cay-90260, Cay-24659) in HepG2 cells. It reduces hepatic steatosis in mice fed a high-fat diet when administered at doses ranging from 5 to 25 mg/kg. 7-ACA (10 mg/kg) inhibits the growth of M. leprae in mice. It is also a potential impurity in commercial preparations of cefoperazone.Formal Name: (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS Number: 957-68-6. Synonyms: 7-ACA. Molecular Formula: C10H12N2O5S. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: CC(OCC1=C(C(O)=O)N(C([C@H]2N)=O)[C@]2([H])SC1)=O. InChi Code: InChI=1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m0/s1. InChi Key: HSHGZXNAXBPPDL-RCOVLWMOSA-N.
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