4E2RCat

4E2RCat is an inhibitor of the protein-protein interaction between eukaryotic translation initiation factor 4E (eIF4E) and eIF4G (IC50 = 13.5 µM). It reduces mRNA translation without inducing apoptosis in L-132 cells when used at a concentration 12.5 µM. 4E2RCat (6 µM) decreases intracellular and extracellular severe acute respiratory coronavirus (SARS-COV) titers and the percentage of cells expressing spike glycoprotein, also known as surface glycoprotein, in SARS-COV-infected L-132 cells.Formal Name: 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid. CAS Number: 432499-63-3. Molecular Formula: C22H14ClNO4S2. Formula Weight: 455.9. Purity: >98% (mixture of isomers). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble, DMSO: Slightly Soluble. SMILES: O=C(C1=C(Cl)C=CC(C2=CC=C(C=C3SC(N(CC4=CC=CC=C4)C3=O)=S)O2)=C1)O. InChi Code: InChI=1S/C22H14ClNO4S2/c23-17-8-6-14(10-16(17)21(26)27)18-9-7-15(28-18)11-19-20(25)24(22(29)30-19)12-13-4-2-1-3-5-13/h1-11H,12H2,(H,26,27). InChi Key: WOBPZFKXPCYOLU-UHFFFAOYSA-N.