2'-O-Methyluridine

2'-O-Methyluridine is a modified nucleoside that has been found in T. thermophila tRNA. Incorporation of 2'-O-methyluridine into siRNA targeting the gene encoding apolipoprotein B (ApoB) decreases ApoB protein levels in HepG2 cells and prevents the production of IFN-alpha in isolated human peripheral blood mononuclear cells (PBMCs) compared with siRNA containing only native nucleosides. Serum levels of 2'-O-methyluridine are decreased in patients with breast cancer.Formal Name: 2'-O-methyl-uridine. CAS Number: 2140-76-3. Synonyms: 2'-O-methyl UR, 1-(2'-O-methyl-beta-D-ribofuranosyl)-Uracil. Molecular Formula: C10H14N2O6. Formula Weight: 258.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 12 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 10 mg/ml. lambdamax: 263 nm. SMILES: CO[C@H]1[C@@](N(C=CC2=O)C(N2)=O)([H])O[C@H](CO)[C@H]1O. InChi Code: InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1. InChi Key: SXUXMRMBWZCMEN-ZOQUXTDFSA-N.