2',3'-Dideoxycytidine-5'-O-(1-thiotriphosphate) (sodium salt)

2',3'-Dideoxycytidine-5'-O-(1-thiotriphosphate) (ddCTP-alpha-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (alpha-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5'-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles. ddCTP-alpha-S has been used for chain extension in PCR assays. ddCTP-alpha-S is a mixture of Rp and Sp isomers.Formal Name: 2',3'-dideoxy-cytidine, 5'->P''-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt. Synonyms: alpha[S]ddCTP, ddCTP-alpha-S. Molecular Formula: C9H12N3O11P3S . 4Na. Formula Weight: 555.2. Purity: >95% (a mixture of Rp and Sp isomers). Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C1N=C(N)C=CN1[C@H]2CC[C@@H](COP([S-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O2.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C9H16N3O11P3S.4Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(21-8)5-20-26(19,27)23-25(17,18)22-24(14,15)16,,,,/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,27)(H2,10,11,13)(H2,14,15,16),,,,/q,4*+1/p-4/t6-,8+,26?,,,,/m0..../s1. InChi Key: NSXFJSOFTIAOQU-LPYYGZKZSA-J.