1,4-DPCA

1,4-DPCA
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay71220-5 5 mg -

6 - 10 business days*

49.00€
Cay71220-10 10 mg -

6 - 10 business days*

88.00€
Cay71220-25 25 mg -

6 - 10 business days*

195.00€
Cay71220-50 50 mg -

6 - 10 business days*

342.00€
 
The pro-angiogenic factor HIF-1alpha is targeted for destruction in non-hypoxic environments by... more
Product information "1,4-DPCA"
The pro-angiogenic factor HIF-1alpha is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-alpha prolyl hydroxylase (HIF-PH). Inhibitors of prolyl 4-hydroxylase are potentially useful in controlling excess collagen deposition in pathological fibrosis. 1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts with an IC50 value of 3.6 and 2.4 µM, respectively. beta-oxocarboxylic acids such as 1,4-DPCA have also been found to inhibit the asparaginyl-hydroxylase, factor inhibiting HIF (FIH), with an IC50 value of 60 µM. Formal Name: 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid. CAS Number: 331830-20-7. Synonyms: 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid. Molecular Formula: C13H8N2O3. Formula Weight: 240.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 216, 242, 261, 280, 317, 332,. SMILES: O=C1C2=C(C3=NC=CC=C3C=C2)N([H])C=C1C(O)=O. InChi Code: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18). InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N.
Keywords: 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid, 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 71220

Properties

Application: Prolyl 4-hydroxylase inhibitor
MW: 240.2 D
Formula: C13H8N2O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 331830-20-7| Find alternatives
KEGG ID : K06711 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "1,4-DPCA"
Write a review
or to review a product.
Viewed