1,1'-Ethylidene-bis-(L-tryptophan)

1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity found in commercial preparations of L-tryptophan. It increases the proliferation of EoL-3 eosinophilic leukemia cells, release of eosinophil cationic protein from isolated human peripheral blood eosinophils, and IL-5 production in isolated human T cells. 1,1'-Ethylidene-bis-(L-tryptophan) (40 µg/kg) induces fascia thickening and increases mast cell infiltration, inflammation, and fibrosis in superficial adipose and panniculus carnosus tissues in mice as a model system of eosinophilia-myalgia syndrome.Formal Name: 1,1'-ethylenebis-L-tryptophan. CAS Number: 132685-02-0. Synonyms: Peak 97 Contaminant, Peak E Contaminant, Peak E Substance. Molecular Formula: C24H26N4O4. Formula Weight: 434.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: 1 M NaOH: soluble. SMILES: CC(N1C2=CC=CC=C2C(C[C@H](N)C(O)=O)=C1)N3C4=CC=CC=C4C(C[C@H](N)C(O)=O)=C3. InChi Code: InChI=1S/C24H26N4O4/c1-14(27-12-15(10-19(25)23(29)30)17-6-2-4-8-21(17)27)28-13-16(11-20(26)24(31)32)18-7-3-5-9-22(18)28/h2-9,12-14,19-20H,10-11,25-26H2,1H3,(H,29,30)(H,31,32)/t19-,20-/m0/s1. InChi Key: DETVQFQGSVEQBH-PMACEKPBSA-N.