Anti-Human BABAM1 Antibody Pair

Product Description: BRISC and BRCA1 A complex member 1 (BABAM1), also known as MERIT40 or NBA1, is a protein encoded by the BABAM1 gene that serves as a critical component of both the BRCA1-A and BRISC multiprotein complexes. BABAM1 is essential for maintaining the integrity and localization of the BRCA1-A complex at sites of DNA double-strand breaks (DSBs), where it specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX. This complex exhibits deubiquitinase activity, removing Lys-63-linked ubiquitin chains, which helps target the BRCA1-BARD1 heterodimer to DNA damage sites and regulates DNA repair pathway choice by promoting non-homologous end joining over homologous recombination. In the BRISC complex, BABAM1 stabilizes BABAM2 and supports Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36, contributing to normal mitotic spindle assembly and microtubule-kinetochore attachment. Additionally, BABAM1 modulates interferon signaling by deubiquitinating the interferon receptor IFNAR1, enhancing its stability and downregulating bacterial lipopolysaccharide responses. Dysfunction or altered expression of BABAM1 impacts DNA repair fidelity and cellular stress responses, implicating it in cancer susceptibility and genomic instability. Protein Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985) [The Uniprot Consortium]