9 products were found matching "Cay11660"!

Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35%...

13,14-dihydro Prostaglandin F2alpha (13,14-dihydro PGF2alpha) is the analog of PGF2alpha which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2alpha. The ED50 value for 13,14-dihydro PGF2alpha as a luteolytic agent in hamsters is 1.5 µg/100...

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110alpha, beta, delta, and gamma with IC50 values of 3, 33, 3, and 75 nM, respectively. It is much less...

Fosmidomycin is an antibiotic originally isolated from culture broths of bacteria of the genus Streptomyces that inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmidomycin is active against both Gram-negative and Gram-positive bacteria and the human malarial...

D2PM (hydrochloride) is a psychoactive designer drug that has recently been demonstrated to have toxic effects in humans. D2PM is also used in organic synthesis to prepare the Corey-Bakshi-Shibata catalyst. This product is intended for forensic purposes.Formal Name: alpha,alpha-diphenyl-2R-pyrrolidinemethanol,...

11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). Boswellic acids are specific, non-redox inhibitors of leukotriene synthesis via 5-lipoxygenase that demonstrate anti-inflammatory and anti-arthritic...

Methedrone (4-methoxymethcathinone) is a substituted cathinone with psychoactive actions. Its use as a recreational drug and its toxicity have recently been reported. 4-methyl-N,N-DMC is an analog of methedrone, differing by the presence of a second aminomethyl group. Its biological and toxicological properties have...

Buphedrone is a substituted cathinone, analogous to methcathinone, which has been identified in products that are sold as stimulants. 4-methyl-N-Methylbuphedrone (hydrochloride) is a para-methyl analog of buphedrone with an aminomethyl addition. Its biological and toxicological properties are not known. This product...

Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities. Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively). It inhibits production of TNF-alpha, IL-1alpha, and IL-1beta and phosphorylation of ERK1/2...