Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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EA-B2L
Item number: TGM-T201479-10mg
Description: EA-B2L is an effective degrader of glutathione S-transferase (GSTP) with a DC50 of 48 µM. It is composed of Ethacrynic acid linked to Boc2Lys. EA-B2L plays a significant role in cancer research. Smiles: C(C(CC)=C)(=O)C1=C(Cl)C(Cl)=C(OCC(NCCCCCCNC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(OC(C)(C)C)=O)=O)=O)C=C1
| MW: | 729.73 D |
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MeS-IMPY
Item number: TGM-T201481-10mg
Description: [11C]MeS-IMPY exhibits a higher binding affinity for beta-amyloid plaques extracted from Alzheimer's disease (AD) brains or AD brain homogenates than IMPY, with Ki values of 7.93 nM and 8.95 nM, respectively. [11C]MeS-IMPY is a potential radioactive ligand for positron emission tomography (PET) imaging...
| MW: | 283.39 D |
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EGFR-IN-135
Item number: TGM-T201484-10mg
Description: EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines. Target: EGFR. Smiles: CC1=C(C2=NN=C(SCC(C)C)O2)N3C(SC=C3)=N1
| MW: | 294.4 D |
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CQ-Mito
Item number: TGM-T201498-10mg
Description: CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP....
| MW: | 841.73 D |
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Anti-MRSA agent 19
Item number: TGM-T201507-10mg
Description: Anti-MRSA agent 19 (Compound 1) is an antibiotic that exhibits activity against Staphylococcus aureus. It is active against 40 clinical isolates from the CDC, representing diverse bacterial species with various resistance factors, including resistance to vancomycin, aminoglycoside/tetracycline, and...
| MW: | 374.6 D |
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CMV-423
Item number: TGM-T201513-10mg
Description: CMV-423 is an antiviral agent exhibiting effective in vitro activity against beta-herpesviruses, including Human Cytomegalovirus (HCMV), Human Herpesvirus 6 (HHV-6), and Human Herpesvirus 7 (HHV-7). It is utilized in antiviral research. Smiles: O=C(N)C=1C(Cl)=C(C=2C=NC=CC2)N3C1CCCC3
| Keywords: | RPR-111423 |
| MW: | 275.73 D |
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LD03-DEX
Item number: TGM-T201519-10mg
Description: LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity. Smiles: F[C@@]12[C@]([C@]3([C@@](C)([C@](C(COC(CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O)(O)[C@H](C)C3)C[C@@H]1O)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
| Keywords: | LD003 |
| MW: | 740.98 D |
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SMARCA2 ligand-8
Item number: TGM-T201520-10mg
Description: SMARCA2 ligand-8 serves as a ligand for the target protein SMARCA2, utilized in the synthesis of PROTAC SMARCA2/4-degrader-35. Target: Ligands for Target Protein for PROTAC. Smiles: IC1=CN2C=C(N=C2N=C1N)C=3C=CC=CC3O
| MW: | 352.13 D |
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FFAR1/FFAR4 agonist-1
Item number: TGM-T201521-10mg
Description: FFAR1/FFAR4 agonist-1 (compound 83) is an agonist targeting both FFAR1 and FFAR4, with EC50 values of 1 nM and 4 nM respectively. This compound is used in research for glycemic control. Smiles: O=C1N(C2=CC(OCC=3N=C(N=C(N3)NCCC4=CC(Cl)=CC=C4Cl)N)=CC(=C2)C)CCC1
| MW: | 487.38 D |
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CQ-16
Item number: TGM-T201540-10mg
Description: CQ-16 is an orally active small molecule drug conjugate (SMDC) that targets prostate-specific membrane antigen (PSMA). It exhibits high selectivity in its antiproliferative activity between PSMA-positive and PSMA-negative prostate cells. Additionally, CQ-16 possesses PARP inhibitory activity (IC50=1...
| MW: | 850.85 D |
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PROTAC SMARCA2 degrader-29
Item number: TGM-T201541-10mg
Description: PROTAC SMARCA2 degrader-29 (Example 87) is a potent PROTAC SMARCA2 (BRM) degrading agent with a DC50 ranging between 10-100 nM (BRM) and over 1 µM (BRG1, also known as SMARCA2). Target: Epigenetic Reader Domain, PROTACs. Smiles:...
| MW: | 875.11 D |
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Utibaprilat
Item number: TGM-T201545-10mg
Description: Utibaprilat is the primary degradation product of Utibapril and functions as an ACE inhibitor. Target: Angiotensin-converting Enzyme (ACE). Smiles: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2[C@H](C(O)=O)SC(C(C)(C)C)=N2
| Keywords: | FPL 63674XX |
| MW: | 421.51 D |
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