Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
No results were found for the filter!
MS 39N
Item number: TGM-T41158-5mg
Description: MS 39N is a negative control for MS 39. Binds EGFR without inducing degradation. Target: Others. References: Cheng et al (2020) Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 63 1216 PMID: 31895569
Please request pricing for this article.
NCT 501 hydrochloride
Item number: TGM-T41159-5mg
Description: NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17beta4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable. Target: Others. References: Yang et al (2015)...
Please request pricing for this article.
ETP 45835 dihydrochloride
Item number: TGM-T41165-5mg
Description: ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein Ki nases, including those upstream of Mnk1/2. Target: Others. References: Oyarzabal et al (2010) Discovery of mitogen-activated protein...
Please request pricing for this article.
NVS PAK1 C
Item number: TGM-T41166-5mg
Description: NVS PAK1 C is a negative control of NVS PAK1 1, a potent and selective PAK1 inhibitor. Target: Others. References: Karpov et al (2015) Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 6 776 PMID: 26191365
Please request pricing for this article.
P21d hydrochloride
Item number: TGM-T41169-5mg
Description: P21d hydrochloride is a potent and selective breast tumor Ki nase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B Ki nase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also activein vivoand...
Please request pricing for this article.
BODIPY FL VH032
Item number: TGM-T41171-5mg
Description: BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL)...
456.00€
*
FAM-DEALA-Hyp-YIPD
Item number: TGM-T41172-1mg
Description: FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1alpha peptide (Kd= 180-560 nM) used to assess VHL binding in Fluorescence Polarization (FP) displacement assays and evaluate the effect of VHL binding on degradation activity. It has an excitation maximum of 485 nm and an emission maximum of 535 nm. A longer...
994.00€
*
FAM-DEALAHypYIPMDDDFQLRSF
Item number: TGM-T41173-1mg
Description: FAM-DEALAHypYIPMDDDFQL RSF is a 5,6-carboxyfluorescein (FAM) labeled HIF-1alpha peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD= 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima...
994.00€
*
Thalidomide-Cyanine 5
Item number: TGM-T41174-1mg
Description: Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET. Target: Others. References: Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012
994.00€
*
Chlorpyrifos-oxon
Item number: TGM-T40642-100mg
Description: Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that significantly inhibits AChE activity and induces cross-linking between tubulin subunits, thereby disrupting microtubule function [4]. Target: Others. Smiles: O=P(OC1=NC(Cl)=C(Cl)C=C1Cl)(OCC)OCC
| MW: | 334.52 D |
From 57.00€
*
Isouvaretin
Item number: TGM-T40695-100mg
Description: Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis. Target: Others. References: Maeda G, et al. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis. J Nat Prod. 2021 Nov 21.
Please request pricing for this article.
iP300v
Item number: TGM-T41181-5mg
Description: iP300v is a negative control for iP300w. Target: Others. References: Bosnakovski et al (2019) A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death. Sci.Adv. 5 eaaw7781 PMID: 31535023
Please request pricing for this article.