Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Cediranib
Item number: TGM-T2500-100mg
Description: Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/=3 nM), similar activity against PDGFRbeta and c-Kit, selective more for VEGFR than PDGFR-alpha (36-fold), CSF-1R (110-fold), and...
| Keywords: | NSC-732208, AZD2171 |
| Application: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 288383-20-0 |
| MW: | 450.51 D |
From 34.00€
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Cediranib maleate
Item number: TGM-T2500L-10mg
Description: Cediranib maleate (AZD2171 maleate) is an orally active and highly potent VEGF family receptor tyrosine kinase (VEGFR2) inhibitor that inhibits Flt1, KDR, Flt4, PDGFRalpha, PDGFRbeta, and c-Kit, and up-regulates MHC-I through transcriptional modulation in the study of ovarian cancer. Target: VEGFR,...
| Keywords: | AZD 2171 maleate , AZD-2171 maleate , AZD2171 maleate |
| MW: | 566.58 D |
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Canertinib dihydrochloride
Item number: TGM-T2501-10mg
Description: Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Target: Virus Protease, EGFR. Smiles: Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
| Keywords: | CI-1033 dihydrochloride , PD-183805 dihydrochloride |
| Application: | Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1) |
| CAS | 289499-45-2 |
| MW: | 558.86 D |
From 30.00€
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PAC-1
Item number: TGM-T2503-100mg
Description: PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others. Target: Apoptosis, Caspase, Autophagy. Smiles: Oc1c(CC=C)cccc1\C=N\NC(=O)CN1CCN(Cc2ccccc2)CC1. References: Putt KS, et al. Nat...
| Keywords: | Procaspase activating compound 1 |
| Application: | Procaspase-3 activator |
| CAS | 315183-21-2 |
| MW: | 392.49 D |
From 30.00€
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Pritelivir
Item number: TGM-T2504-100mg
Description: Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM). Target: DNA/RNA Synthesis, HSV. Smiles: CN(C(=O)Cc1ccc(cc1)-c1ccccn1)c1nc(C)c(s1)S(N)(=O)=O. References: Kleymann G, et al. Nat Med. 2002, 8(4), 392-398.
| Keywords: | AIC316, BAY 57-1293 |
| Application: | Antiviral, Helicase-primase inhibitor |
| CAS | 348086-71-5 |
| MW: | 402.49 D |
From 30.00€
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S3I-201
Item number: TGM-T2505-100mg
Description: S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 µM) and low effect towards STAT1/5. Target: STAT. Smiles: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1. References: Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening,...
| Keywords: | S3I201, S3I 201 |
| Application: | STAT3 inhibitor |
| CAS | 501919-59-1 |
| MW: | 365.36 D |
From 48.00€
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AZD-5438
Item number: TGM-T2506-100mg
Description: AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM). Target: CDK. Smiles: CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1. References: Byth KF, et al. Mol Cancer Ther. 2009, 8(7), 1856-1866.
| Keywords: | AZD5438 |
| Application: | Cdk1 / Cdk2 / Cdk9 inhibitor |
| CAS | 602306-29-6 |
| MW: | 371.46 D |
From 42.00€
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Azeliragon
Item number: TGM-T2507-100mg
Description: Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products, is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD). Target: Beta Amyloid, advanced glycation end products. Smiles:...
| Keywords: | TTP488 |
| Application: | Dementia therapeutic agent |
| CAS | 603148-36-3 |
| MW: | 532.12 D |
From 32.00€
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Ambamustine HCl
Item number: TGM-T2507L-100mg
Description: Ambamustine HCl is a novel tripeptide anticancer. Target: Others. Smiles: N(CCCl)(CCCl)C1=CC(C[C@@H](C(N[C@H](C(OCC)=O)CCSC)=O)NC([C@H](CC2=CC=C(F)C=C2)N)=O)=CC=C1.Cl. References: Ardizzoni A, Antonelli G, Ricci S, Frasci G, Rinaldi M, Boni L, Galletti P, Pennucci MC, Antonuzzo A, Gravina A, Galli L,...
| Keywords: | PT 119, Ptt-119, Ptt 119, PT119, PT-119, Ambamustine hydrochloride |
| CAS | 83996-50-3 |
| MW: | 666.08 D |
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Azeliragon HCl
Item number: TGM-T2507L2-100mg
Description: Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. Target: Others. Smiles:...
| Keywords: | Azeliragon dihydrochloride, TTP-488, TTP 488, Azeliragon hydrochloride, TTP488 HCl |
| CAS | 1284150-65-7 |
| MW: | 605.04 D |
From 1,440.00€
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Tozasertib
Item number: TGM-T2509-100mg
Description: Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases. Target: Aurora Kinase, Autophagy. Smiles: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1. References: Harrington EA, et...
| Keywords: | MK-0457, VX 680 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 639089-54-6 |
| MW: | 464.59 D |
From 48.00€
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Bucloxic acid calcium salt
Item number: TGM-T23832-100mg
Description: Bucloxic acid calcium salt is a pyrazole derivative, the calcium salt of Bucloxic acid. It is an anti-inflammatory drug with analgesic and antipyretic properties. It is also used in the study of chronic glomerulonephropathy. Target: Others. Smiles:...
| Keywords: | Bucloxic acid calcium, CB 804 calcium, Calcium esfar |
| CAS | 32808-53-0 |
| MW: | 631.64 D |
From 1,440.00€
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