Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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BMS-214662 mesylate
Item number: TGM-T204276-10mg
Description: BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research. Target: Transferase. Smiles: S(C)(=O)(=O)O.C([C@H]1N(S(=O)(=O)C2=CC=CS2)CC=3C(N(CC4=CN=CN4)C1)=CC=C(C#N)C3)C5=CC=CC=C5
| MW: | 585.718 D |
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Desthiazolylmethyl ritonavir
Item number: TGM-T204277-10mg
Description: Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir. Target: HIV Protease. Smiles: C([C@H](CC1=CC=CC=C1)NC([C@@H](NC(N(CC=2N=C(C(C)C)SC2)C)=O)[C@H](C)C)=O)[C@H]3[C@H](CC4=CC=CC=C4)NC(=O)O3
| MW: | 605.791 D |
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AK-968-11563024
Item number: TGM-T204280-10mg
Description: AK-968-11563024 is an inhibitor targeting marine V. vulnificus NAT [(VIBVN)NAT] with an IC50 value of 18.86 µM. In V. vulnificus, NAT (aromatic amine N-acetyltransferase) plays a role in drug metabolism, contributing to drug resistance. Thus, AK-968-11563024 can be used for research related to drug...
| MW: | 689.162 D |
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Doxazosin impurity 12
Item number: TGM-T204282-10mg
Description: Doxazosin impurity 12 acts as an inhibitor of CTX-M beta-lactamase (Beta-lactamase) with a Ki value of 0.7 mM against CTX-M. Target: Antibacterial, Beta-lactamase. Smiles: O=C1C=C(C=2C=CC=CC2C1=O)S(=O)(=O)O
| MW: | 238.217 D |
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DNA polymerase-IN-6
Item number: TGM-T204284-10mg
Description: DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV. Target: HSV, Virus Protease, DNA/RNA Synthesis. Smiles:...
| MW: | 571.003 D |
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AV457
Item number: TGM-T204285-10mg
Description: AV457 is a potent and selective inhibitor of mTOR. It effectively suppresses cyst growth in polycystic kidney disease (PKD) organoids. AV457 reduces the protein expression of P-s6 and P-p70s6, but it does not decrease the protein expression of P-AKT. Target: mTOR. Smiles:...
| MW: | 1065.36 D |
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GLP-1R agonist 27
Item number: TGM-T204289-10mg
Description: GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. It enhances the accumulation of cyclic adenosine monophosphate (cAMP), reduces blood glucose levels, and decreases food intake. GLP-1R agonist 27 shows potential for research in obesity and type 2 diabetes mellitus (T2DM)....
| MW: | 630.6 D |
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ROMK-IN-2
Item number: TGM-T204293-10mg
Description: ROMK-IN-2 (compound 1) is an effective inhibitor of renal outer medullary potassium (ROMK). Target: Potassium Channel. Smiles: CC=1C(=CC=C2C1COC2=O)[C@@H]3CN(CC4=CC(=NO4)C5=CC(C)=C(C#N)C=N5)CC[C@H]3O
| MW: | 444.483 D |
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DNA gyrase/Topo IV-IN-1
Item number: TGM-T204302-10mg
Description: DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM...
| MW: | 729.941 D |
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BMS-818251
Item number: TGM-T204307-10mg
Description: BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the...
| MW: | 570.619 D |
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Glutathione monoethyl ester
Item number: TGM-T204308-10mg
Description: Glutathione monoethyl ester, a derivative of glutathione, can protect motor neuron cells (NSC-34) from TDP-43 pathology caused by mutations, which includes reducing aggregate formation, nuclear clearance, reactive oxygen species (ROS) production, and cell death. Target: Reactive Oxygen Species. Smiles:...
| MW: | 335.377 D |
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Casein kinase 1delta-IN-20
Item number: TGM-T204309-10mg
Description: Casein kinase1delta-IN-20 (compound 427) is an effective inhibitor of casein kinase1delta. It is applicable in research related to neurodegenerative diseases, such as Alzheimer's disease. Target: Casein Kinase. Smiles: O=C(C=1C=C(N(C1C)C)C)COC2=NC=NC=3SC=CC23
| MW: | 301.364 D |
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