Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Ningetinib
Item number: TGM-TQ0021-100mg
Description: Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively. Target: c-Met/HGFR, TAM Receptor, VEGFR. Smiles: Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C. References: Ning...
| Keywords: | CT053PTSA, CT-053 |
| Application: | Tyrosine kinase inhibitor |
| CAS | 1394820-69-9 |
| MW: | 556.58 D |
From 40.00€
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Capromorelin Tartrate
Item number: TGM-TQ0022-100mg
Description: Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a). Target: GHSR. Smiles: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1N=C2CCN(C[C@@]2(Cc2ccccc2)C1=O)C(=O)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N. References: Carpino PA, et al....
| Keywords: | CP 424391-18 |
| Application: | Targets growth hormone secretagogue receptor (GHSR) |
| CAS | 193273-69-7 |
| MW: | 655.7 D |
From 32.00€
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Lorediplon
Item number: TGM-TQ0023-100mg
Description: Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep. Target: GABA Receptor. Smiles: CN(C(C)=O)c1cc(ccc1F)-c1ccnc2c(cnn12)C(=O)c1cccs1. References: Horoszok L, et al. A single-dose, randomized,...
| Application: | GABRA1 ligand |
| CAS | 917393-39-6 |
| MW: | 394.42 D |
From 38.00€
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E7046
Item number: TGM-TQ0025-10mg
Description: E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. Target: Prostaglandin Receptor. Smiles: C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O. References: Diana I. Albu, et al. EP4 Antagonism by E7046 diminishes...
| Application: | EP4 antagonist |
| CAS | 1369489-71-3 |
| MW: | 483.4 D |
From 46.00€
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MDR-1339
Item number: TGM-TQ0026-100mg
Description: MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-beta (Abeta) aggregation. Target: Gamma-secretase, Beta Amyloid. Smiles: COCCCc1ccc2oc(cc2c1)-c1ccc(OC)c(OC)c1. References: Ha HJ, et al. Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a...
| Keywords: | DWK-1339 |
| Application: | beta-amyloid protein aggregation inhibitor |
| CAS | 1018946-38-7 |
| MW: | 326.39 D |
From 51.00€
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Transcrocetinate disodium
Item number: TGM-TQ0027-100mg
Description: Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor. Target: NMDAR, iGluR. Smiles: O=C([O-])/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C([O-])=O.[Na+].[Na+]. References: Lautenschläger M, et al. Intestinal...
| Keywords: | Disodium trans-crocetinate |
| CAS | 591230-99-8 |
| MW: | 372.37 D |
From 37.00€
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EX229
Item number: TGM-TQ0028-100mg
Description: EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 µM, 0.06 µM and 0.51 µM for alpha1beta1gamma1, alpha2beta1gamma1, and alpha1beta2gamma1, respectively. Target: AMPK. Smiles: Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc3n(C)ccc3c2)cc1C(O)=O. References: Xiao B, et al. Structural basis of AMPK...
| Keywords: | Compound 991, C991 |
| Application: | AMPK activator |
| CAS | 1219739-36-2 |
| MW: | 431.87 D |
From 30.00€
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ASTX660
Item number: TGM-TQ0029-100mg
Description: ASTX660 is an orally bioavailable dual antagonist of cIAP (cellular inhibitor of apoptosis protein) and XIAP (X-linked inhibitor of apoptosis protein). Target: IAP. Smiles: C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nc(CO)c(Cc4ccc(F)cc4)cc23)[C@@H](CN2CCOC[C@H]2C)CN1. References: Tomoko Smyth, et al. Abstract 1287:...
| Application: | IAP protein-peptide interaction non-peptidomimetic inhibitor |
| CAS | 1799328-86-1 |
| MW: | 539.68 D |
From 72.00€
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Tomeglovir
Item number: TGM-TQ0030-2mg
Description: Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 µM for HCMV and MCMV). Target: HCV Protease. Smiles: CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1ccc(NC(=O)C(C)(C)CO)cc1. References: Weber O, et al. Inhibition of murine cytomegalovirus and human...
| Keywords: | BAY 38-4766 |
| CAS | 233254-24-5 |
| MW: | 441.54 D |
49.00€
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Rosiptor
Item number: TGM-TQ0032-10mg
Description: Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects. Target: Phosphatase. Smiles: [H][C@@]12CCC(=C)[C@@]1(C)CC[C@@]([H])([C@H]2CN)[C@@]1(C)CC[C@H](O)C[C@@H]1CO. References: Stenton GR, et al. Characterization of AQX-1125, a...
| Keywords: | AQX-1125 |
| Application: | Targets phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86] (SHIP1, INPP5D) |
| CAS | 782487-28-9 |
| MW: | 321.5 D |
From 106.00€
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Rosiptor acetate
Item number: TGM-TQ0032L-100mg
Description: Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast cells and inhibits human leukocyte chemotaxis. AQX-1125 suppresses leukocyte...
| Keywords: | AQX-1125 acetate, AQX1125, AQX-1125, AQX 1125 |
| Application: | Targets phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86] (SHIP1, INPP5D) |
| CAS | 782487-29-0 |
| MW: | 381.55 D |
From 2,437.00€
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Zegocractin
Item number: TGM-TQ0033-100mg
Description: Zegocractin (CM-4620) is an inhibitor of calcium-release activated calcium (CRAC) channels. Target: Calcium Channel. Smiles: Cc1cccc(F)c1C(=O)Nc1cnc(cn1)-c1cc2OC(F)(F)Oc2cc1Cl. References: ARYL SULFONOHYDRAZIDES. WO2016/138472Al.
| Keywords: | CM4620, N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide, CM-4620 |
| CAS | 1713240-67-5 |
| MW: | 421.76 D |
From 121.00€
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