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Description: EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 µM, 0.06 µM and 0.51 µM for alpha1beta1gamma1, alpha2beta1gamma1, and alpha1beta2gamma1, respectively. Target: AMPK. Smiles: Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc3n(C)ccc3c2)cc1C(O)=O. References: Xiao B, et al. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013,4:3017.
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