Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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HDAC8-IN-5
Item number: TGM-T78861-50mg
Description: HDAC8-IN-5 (Compound 6a), with an inhibitory concentration (IC50) of 28 nM, is a potent HDAC8 inhibitor suitable for cancer research [1]. Target: HDAC
| MW: | 277.23 D |
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EGFR-IN-86
Item number: TGM-T78862-50mg
Description: EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1]. Target: EGFR
| MW: | 423.49 D |
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HSP90-IN-25
Item number: TGM-T78863-50mg
Description: HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically impedes its ATPase function [1]. Target: HSP
| MW: | 556.69 D |
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alpha-Glucosidase-IN-33
Item number: TGM-T78864-50mg
Description: alpha-Glucosidase-IN-33 (compound 7c), with an IC50 of 2.39 µM, is a potent alpha-glucosidase inhibitor, pertinent to type 2 diabetes and hyperglycemia research [1]. Target: Glucosidase
| MW: | 480.44 D |
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alpha-Glucosidase-IN-34
Item number: TGM-T78865-50mg
Description: alpha-Glucosidase-IN-34 (compound 7f) is a potent alpha-glucosidase inhibitor with an IC50 of 2.90 µM, applicable in type 2 diabetes and hyperglycemia research [1]. Target: Glucosidase
| MW: | 448.47 D |
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DNA Gyrase-IN-9
Item number: TGM-T78866-50mg
Description: DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase and exhibits a minimum inhibitory concentration (MIC) of 0.5-2 µg/mL for Gram-positive bacteria inhibition and a minimum bactericidal concentration (MBC) of 2-8 µg/mL for Gram-positive bacteria eradication. Notably,...
| MW: | 439.89 D |
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TWIK-1/TREK-1-IN-1
Item number: TGM-T78868-100mg
Description: Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound,...
| CAS | 1440532-30-8 |
| MW: | 395.42 D |
From 1,440.00€
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TWIK-1/TREK-1-IN-2
Item number: TGM-T78869-100mg
Description: TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values of 10.13 µM and 15.5 µM, respectively, additionally, it exhibits antidepressant properties [1]. Target: Potassium Channel
| CAS | 1440532-32-0 |
| MW: | 386.45 D |
From 1,440.00€
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PLM-101
Item number: TGM-T78871-50mg
Description: PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET. It impedes RET function, promoting autophagic breakdown of FLT3, and suppresses the PI3K and Ras/ERK pathways, contributing to its anti-leukemic effects. The compound's antitumor efficacy is...
| MW: | 407.44 D |
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CTL-12
Item number: TGM-T78873-50mg
Description: CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 µM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apoptotic marker Bcl-xL. By inhibiting de novo lipogenesis, CTL-12 thwarts tumor cells'...
| MW: | 440.88 D |
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GSK-3beta inhibitor 15
Item number: TGM-T78874-50mg
Description: GSK-3beta inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Abeta 1-42-induced phosphorylation of GSK-3beta and tau protein, as well as LPS-induced iNOS expression, demonstrating neuroprotective properties against Abeta 1-42-induced neurotoxicity and indicating potential utility...
| MW: | 352.41 D |
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MTX-241F
Item number: TGM-T78877-50mg
Description: MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families. It penetrates the blood-brain barrier, providing long-term tumor growth control and exhibits radiosensitizing activity in patient-derived DIPG neurospheres, potentially beneficial for studying diffuse...
| MW: | 392.82 D |
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