36 products were found matching "K17816"!

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell...

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH588 is an MTH1 inhibitor (IC50 = 5 nM) with improved metabolic stability over...

(S)-Crizotinib is an inhibitor of muT homolog 1 (MTH1, IC50 = 72 nM). It is selective for MTH1 over a panel of 456 kinases at 1 µM. (S)-Crizotinib (30 µM) induces oxidative DNA damage and apoptosis in SGC-7901 and BGC-823 human gastric cancer cells. It inhibits proliferation in a panel of 14 cancer cell lines...

Protein function: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently...

SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts. At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on...

Protein function: Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative...

3-Isomangostin is a xanthone and alpha-mangostin (Cay-29108) derivative that has been found in G. mangostana and has diverse biological activities. It is an inhibitor of mutT homolog 1 (MTH1, IC50 = 52 nM). 3-Isomangostin also inhibits aldose reductase (IC50 = 3.48 µM), acetylcholinesterase (AChE, IC50 = 2.36...

Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: Tag-Free. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ...

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 19-197aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE...

Description: TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells. Target: MTH1, DNA/RNA Synthesis. Smiles: Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl. References: Gad H, et al. Nature. 2014, 508(7495), 215-221.