3-Isomangostin

3-Isomangostin is a xanthone and alpha-mangostin (Cay-29108) derivative that has been found in G. mangostana and has diverse biological activities. It is an inhibitor of mutT homolog 1 (MTH1, IC50 = 52 nM). 3-Isomangostin also inhibits aldose reductase (IC50 = 3.48 µM), acetylcholinesterase (AChE, IC50 = 2.36 µg/ml), and butyrylcholinesterase (BChE, IC50 = 5.32 µg/ml). It inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 µg/ml, respectively). 3-Isomangostin inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively).Formal Name: 3,4-dihydro-5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-pyrano[3,2-b]xanthen-6-one. CAS Number: 19275-46-8. Molecular Formula: C24H26O6. Formula Weight: 410.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. SMILES: O=C1C2=C(OC3=CC(O)=C(C(C/C=C(C)\C)=C13)OC)C=C(OC(C)(CC4)C)C4=C2O. InChi Code: InChI=1S/C24H26O6/c1-12(2)6-7-14-19-17(10-15(25)23(14)28-5)29-18-11-16-13(8-9-24(3,4)30-16)21(26)20(18)22(19)27/h6,10-11,25-26H,7-9H2,1-5H3. InChi Key: KJCDBAVVDILRMP-UHFFFAOYSA-N. Origin: Plant/Garcinia mangostana L..