C12 Ceramide (d18:1/12:0)

C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM). It is a substrate for acid ceramidase, an enzyme that has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease, a lipid storage disorder. C12 ceramide is found in the Wharton's jelly, a protective coating that surrounds umbilical cord vessels, of babies born to women with pre-eclampsia. BODIPY C12 ceramide has been used to assess levels of ASM activity in plasma of patients with type A or B Niemann-Pick disease.Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-dodecanamide. CAS Number: 74713-60-3. Synonyms: Cer(d18:1/12:0), C12 Ceramide, Ceramide (d18:1/12:0), N-Lauroyl-D-erythro-Sphingosine. Molecular Formula: C30H59NO3. Formula Weight: 481.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.50 mg/ml. SMILES: OC[C@H](NC(CCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C30H59NO3/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-29(33)28(27-32)31-30(34)26-24-22-20-17-12-10-8-6-4-2/h23,25,28-29,32-33H,3-22,24,26-27H2,1-2H3,(H,31,34)/b25-23+/t28-,29+/m0/s1. InChi Key: HXFPPRPLRSPNIB-VARSQMIESA-N.