147 products were found matching "K11793"!
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Cereblon/CRBN Protein, Rat, Recombinant (His)
Item number: TGM-TMPH-03356-10ug
Description: Cereblon/CRBN Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 52.4 kDa and the accession number is Q56AP7.
| Keywords: | Protein cereblon , Crbn |
| MW: | 52.4 kD |
From 273.00€
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CRBN/DDB1 Complex (human, recombinant)
Item number: Cay45180-100
Source: Active recombinant human N-terminal His-AVI-tagged CRBN and DDB1 expressed in insect cells . Amino acids: 1-442 (CRBN) (full length), 1-1,140 (DDB1) (full length) . MW: 55.3 (CRBN) and 126.9 (DDB1) kDa. Protein Function: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex...
| Keywords: | CRBN, Protein cereblon |
From 1,294.00€
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CRBN/DDB1/Cullin 4A/RBX1 Complex (human, recombinant)
Item number: Cay45181-50
Source: Active recombinant human N-terminal His-AVI-tagged CRBN, DDB1, cullin 4A, and RBX1 expressed in insect cells . Amino acids: 1-442 (CRBN) (full length), 1-1,140 (DDB1) (full length), 2-759 (cullin 4A) (full length), 1-108 (RBX1) (full length) . MW: 55.3 (CRBN), 126.9 (DDB1), 87.6 (cullin 4A), and 12.2 (RBX1)...
| Keywords: | CRBN, Protein cereblon |
1,354.00€
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CRBNmidi (human, recombinant)
Item number: Cay45179-10
Source: Recombinant human N-terminal His-tagged CRBNmidi expressed in E. coli Amino acids: 41-187-GSG-249-426 MW: 39.8 kDa. SMILES: . InChi Code: . InChi Key:
| Keywords: | Cereblonmidi |
| Expressed in: | E. coli |
From 356.00€
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Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His)
Item number: TGM-TMPH-01931-10ug
Description: Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) is expressed in in vitro E. coli expression system.
| Keywords: | CRBN , Protein cereblon |
| MW: | 51.2 kD |
From 260.00€
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Cereblon/CRBN Protein, Human, Recombinant (His)
Item number: TGM-TMPH-01932-10ug
Description: Cereblon/CRBN Protein, Human, Recombinant (His) is expressed in Baculovirus.
| Keywords: | CRBN , Protein cereblon |
| MW: | 53.4 kD |
From 149.00€
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Anti-CRBN / Cereblon
Item number: NSJ-FY12446
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. CRBN antibody recognizes Cereblon, a substrate receptor component of the CRL4 E3 ubiquitin ligase complex that plays a central role in targeted protein degradation. Cereblon binds to the DDB1-CUL4-ROC1 complex, recruiting specific substrates...
| Keywords: | Anti-CRBN, Anti-Protein cereblon, CRBN Antibody / Cereblon |
| Application: | WB, ICC/IF, FC, ELISA |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
790.00€
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TD-106
Item number: Cay44836-10
TD-106 is a modulator of cereblon. It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0....
| Keywords: | 3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2,6-piperidinedione |
| Application: | Cereblon modulator |
| CAS | 2250288-69-6 |
| MW: | 273.25 D |
From 244.00€
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TD-165
Item number: Cay44837-1
TD-165 is a proteolysis-targeting chimera (PROTAC) that contains VH 032 (Cay-39982) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HEK293T cells with a half-maximal degradation concentration (DC50) value of 20. nM. TD-165 (0. µM) increases L-type voltage-gated...
| Keywords: | (2S,4R)-1-((2S)-2-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethyl-butanoyl)-4-... |
| Application: | CRBN degradation driving PROTAC |
| CAS | 2305936-56-3 |
| MW: | 870.08 D |
From 79.00€
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CC-885
Item number: Cay19966-1
CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines. It forms a complex with cereblon and the cell cycle regulator and translation termination factor GSPT1. The antitumour activity of CC-885 relies on cereblon-dependent ubiquitination and...
| Keywords: | N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea |
| Application: | CRBN modulator |
| CAS | 1010100-07-8 |
| MW: | 440.9 D |
From 139.00€
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Golcadomide
Item number: Cay44114-1
Golcadomide is a cereblon (CRBN) E3 ligase modulator (CELMoD). It decreases protein levels of Ikaros family zinc finger protein 1 (IKZF1) and IFN regulatory factor 4 (IRF4) in JSC-1, BCBL-1, Daudi, and BL-41 lymphoma cells when used at a concentration of 0. µM and decreases the viability of these cells in a...
| Keywords: | CC-99282,... |
| Application: | Cereblon modulator, CELMoD, antineoplastic, thalidomide derivative |
| CAS | 2379572-34-4 |
| MW: | 535.58 D |
From 254.00€
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Cereblon Binding Assay Kit
Item number: BPS-79899
The Cereblon Binding Assay Kit (FP) is designed for testing and profiling of Cereblon (CRBN) inhibitors using Fluorescence Polarization. The assay is a competitive binding assay, based on the binding of fluorescently-labeled Thalidomide, a CRBN binder, to purified recombinant CRBN. CRBN is the substrate recognition...
| Keywords: | CRBN, AD-006, Protein cereblon |
| Application: | Enzyme kinetics, drug discovery, HTS |
| Species reactivity: | human |
1,482.00€
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