133 products were found matching "K11793"!
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Protein cereblon (CRBN), recombinant human
Item number: CSB-MP842761HU.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 1-442aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE...
| Keywords: | CRBN, AD-006, Protein cereblon |
| Application: | Activity not tested |
| Expressed in: | Mammalian cells |
| Origin: | human |
| MW: | 53.0 kD |
From 371.00€
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EM12-SO2F
Item number: Cay41446-10
EM12-SO2F is a covalent inhibitor of cereblon (CRBN, IC50 = 0.88 nM). It inhibits the degradation of Ikaros family zinc finger protein 1 (IKZF1) induced by the thalidomide derivative lenalidomide (Cay-14643) in MOLT-4 lymphoblasts when used at a concentration of 1 µM.Formal Name:...
| Keywords: | 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride |
| Application: | Covalent cereblon inhibitor |
| CAS | 2803819-61-4 |
| MW: | 326.3 D |
From 103.00€
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PROTAC CRBN Degrader-1
Item number: Cay41878-1
PROTAC CRBN degrader-1 is a proteolysis-targeting chimera (PROTAC) that contains VHL ligand 1 (Cay-21591) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HeLa cells with a half-maximal degradation concentration (DC50) value of 200 nM.Formal Name:...
| Keywords: | PROTAC Cereblon Degrader-1, Proteolysis-targeting Chimera Cereblon Degrader-1, Proteolysis-targeting Chimera CRBN... |
| Application: | CRBN degradation driving PROTAC |
| CAS | 2358775-70-7 |
| MW: | 1061.3 D |
From 171.00€
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Thalidomide-O-C6-NH2 hydrochloride
Item number: TGM-T40031-100mg
Description: Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) is a synthesized E3 ligase ligand-linker conjugate. Target: E3 Ligase Ligand-Linker Conjugate. Smiles: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.[H]Cl. References: Erb MA, et...
| Keywords: | 4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride |
| Application: | Protac(R) reagent |
| CAS | 2245697-88-3 |
| MW: | 409.86 D |
From 40.00€
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dBET1
Item number: TGM-T4495-100mg
Description: dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis. Target: Epigenetic Reader Domain, PROTACs. Smiles:...
| Application: | Protac(R) reagent |
| CAS | 1799711-21-9 |
| MW: | 785.27 D |
From 48.00€
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dBET6
Item number: TGM-T5130-100mg
Description: dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity. Target: Apoptosis, Epigenetic Reader Domain, PROTACs. Smiles: CC=1C2=C(N3C([C@H](CC(NCCCCCCCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C....
| Application: | Protac(R) reagent |
| CAS | 1950634-92-0 |
| MW: | 841.37 D |
From 48.00€
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ARV-825
Item number: TGM-T5434-100mg
Description: ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. Target: Epigenetic Reader Domain, PROTACs. Smiles:...
| Application: | Protac(R) reagent |
| CAS | 1818885-28-7 |
| MW: | 923.43 D |
From 60.00€
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CFT7455
Item number: TGM-T60024-10mg
Description: CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3). Target: Ligand for E3 Ligase. Smiles:...
| Keywords: | Cemsidomide |
| Application: | Protac(R) reagent |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
From 79.00€
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Thalidomide-O-COOH
Item number: TGM-T7753-1mL
Description: Thalidomide-O-COOH (Cereblon ligand 3) is a Thalidomide-based Cereblon ligand utilized for recruiting the CRBN protein and can be linked to a protein ligand via a linker to create PROTACs. Target: Others, Ligand for E3 Ligase. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(O)=O
| Keywords: | Cereblon ligand 3, E3 ligase Ligand 3, TCE35031 |
| Application: | Protac(R) reagent |
| CAS | 1061605-21-7 |
| MW: | 332.27 D |
From 30.00€
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Thalidomide 4-fluoride
Item number: TGM-T7755-500mg
Description: Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4...
| Keywords: | E3 ligase Ligand 4 |
| Application: | Protac(R) reagent |
| CAS | 835616-60-9 |
| MW: | 276.22 D |
30.00€
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Pomalidomide-PEG4-Ph-NH2
Item number: TGM-T7756-100mg
Description: Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate that integrates a Pomalidomide-based cereblon ligand with a 4-unit PEG linker. Target: Ligand for E3 Ligase. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCO CCOC4=CC=C(N)C=C4. References: Andrew P. Crew, et al....
| Application: | Protac(R) reagent |
| CAS | 1818885-63-0 |
| MW: | 540.57 D |
From 31.00€
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Thalidomide-4-OH
Item number: TGM-T7763-500mg
Description: Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs. Target: Ligand for E3 Ligase. Smiles: OC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O. References: Marks MG, et...
| Keywords: | Cereblon ligand 2, E3 ligase Ligand 2 |
| Application: | Protac(R) reagent |
| CAS | 5054-59-1 |
| MW: | 274.23 D |
30.00€
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