142 products were found matching "K11793"!

Source: Recombinant human N-terminal His-tagged CRBNmidi expressed in E. coli  Amino acids: 41-187-GSG-249-426  MW: 39.8 kDa. SMILES: . InChi Code: . InChi Key:

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. CRBN antibody recognizes Cereblon, a substrate receptor component of the CRL4 E3 ubiquitin ligase complex that plays a central role in targeted protein degradation. Cereblon binds to the DDB1-CUL4-ROC1 complex, recruiting specific substrates...

TD-106 is a modulator of cereblon. It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0....

TD-165 is a proteolysis-targeting chimera (PROTAC) that contains VH 032 (Cay-39982) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HEK293T cells with a half-maximal degradation concentration (DC50) value of 20. nM. TD-165 (0. µM) increases L-type voltage-gated...

Golcadomide is a cereblon (CRBN) E3 ligase modulator (CELMoD). It decreases protein levels of Ikaros family zinc finger protein 1 (IKZF1) and IFN regulatory factor 4 (IRF4) in JSC-1, BCBL-1, Daudi, and BL-41 lymphoma cells when used at a concentration of 0. µM and decreases the viability of these cells in a...

CC-885 is a modulator of the E3 ligase protein cereblon with antiproliferative effects on human myeloid leukemia cell lines. It forms a complex with cereblon and the cell cycle regulator and translation termination factor GSPT1. The antitumour activity of CC-885 relies on cereblon-dependent ubiquitination and...

PT-179 is a molecular glue and ligand for the E3 ubiquitin ligase cereblon. It has been used in conjunction with the zinc finger degron SD40 to induce degradation of SD40-tagged proteins.. Solulibility: DMSO: Soluble: = 10 mg/ml: .

The Cereblon Binding Assay Kit (FP) is designed for testing and profiling of Cereblon (CRBN) inhibitors using Fluorescence Polarization. The assay is a competitive binding assay, based on the binding of fluorescently-labeled Thalidomide, a CRBN binder, to purified recombinant CRBN. CRBN is the substrate recognition...

dBET1 is a hybrid molecule that combines (+)-JQ1 (Cay-11187) and thalidomide (Cay-14610). The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition...

(±)-Thalidomide is an immunomodulatory compound with diverse biological activities, including anticancer, anti-inflammatory, and teratogenic properties. It prevents polymorphonuclear leukocyte (PMN) chemotaxis when used at concentrations of 1, 10, and 100 µg/ml. (±)-Thalidomide increases IL-2-induced proliferation...

Pomalidomide is an analog of thalidomide (Cay-14610) that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 µM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 318-426aa. Protein Length: Partial. Tag Info: N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged. Target Protein Sequence: CTSLCCKQCQ ETEITTKNEI FSLSLCGPMA AYVNPHGYVH ETLTVYKACN LNLIGRPSTE HSWFPGYAWT VAQCKICASH IGWKFTATKK DMSPQKFWGL TRSALLPTI....