TD-106

TD-106 is a modulator of cereblon. It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0. µM). It also reduces tumor growth in a TMD8 diffuse large B cell lymphoma (DLBCL) mouse xenograft model when administered at a dose of 50 mg/kg per day. TD-106 has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) with anticancer activity. Formal Name: 3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2,6-piperidinedione. CAS Number: 2250288-69-6. Molecular Formula: C12H11N5O3. Formula Weight: 273.3. Purity: >95%. Formulation (Request formulation change): A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C1NC(C(CC1)N2C(C3=C(N=N2)C=CC=C3N)=O)=O. InChi Code: InChI=1S/C12H11N5O3/c13-6-2-1-3-7-10(6)12(20)17(16-15-7)8-4-5-9(18)14-11(8)19/h1-3,8H,4-5,13H2,(H,14,18,19). InChi Key: DXZBHVQOULDEPN-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.