33 products were found matching "K11436"!

Description: XY1 is a close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), intended as a negative control for SGC707 in studies involving PRMT3 action. Target: Histone Methyltransferase. Smiles: O=C(CNC(=O)Nc1ccc2ccccc2c1)N1CCCC1. References: Børsting C, Tomas C,...

Description: Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3 gene. Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The...

Description: UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM). Target: Others. Smiles: N(C(NCC(=O)N1CCCCC1)=O)C=2C=C3C(=CC2)N=NS3

Description: SGC707 is a potent, selective, and cell-active allosteric inhibitor of [PRMT3]. Target: Histone Methyltransferase. Smiles: O=C(NCC(=O)N1CCCC1)Nc1ccc2cnccc2c1. References: Kaniskan HÜ, et al. Angew Chem Int Ed Engl. 2015 Apr 20,54(17):5166-70.

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PRMT3. Antigen Species: Human

Active human PRMT3, GenBank Accession No. NM_005788, amino-acids 2-end, with N-terminal GST tag, MW=86 kDa, expressed in an E. coli expression system.

Protein function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. [The UniProt Consortium]

Protein function: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. [The UniProt Consortium]

Protein arginine N-methyltransferase 3 (PRMT3, Cay-11642) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural...

Protein arginine N-methyltransferase 3 (PRMT3, Cay-11642) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 (Cay-17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close...

UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3, IC50 = 230 nM).Formal Name: N-1,2,3-benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]-urea. CAS Number: 1426152-53-5. Molecular Formula: C14H17N5O2S. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change),...

The PRMT3 Homogenous Assay Kit is designed to measure activity of the PRMT3 using purified enzyme complex or cell extracts containing PRMT3. PRMT3 is a histone methyltransferase that exhibits methylation activity toward H4-R3. The PRMT3 Homogenous Assay Kit comes in a convenient AlphaScreen or AlphaLISA format, with...