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Protein arginine N-methyltransferase 3 (PRMT3, Cay-11642) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 (Cay-17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea. CAS Number: 1624117-53-8. Molecular Formula: C17H19N3O2. Formula Weight: 297.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 245 nm. SMILES: O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=CC=C3C=C2. InChi Code: InChI=1S/C17H19N3O2/c21-16(20-9-3-4-10-20)12-18-17(22)19-15-8-7-13-5-1-2-6-14(13)11-15/h1-2,5-8,11H,3-4,9-10,12H2,(H2,18,19,22). InChi Key: GSQHGSRPQHBTTP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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