36 products were found matching "K08402"!

Recombinant CHO-K1 cells stably overexpress human nicotinic acid receptor (NIACR1), also known as hydroxycarboxylic acid receptor 2 (HCAR2), on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

Rabbit Polyclonal HCAR3 Antibody against Human hydroxycarboxylic acid receptor 3. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000042133: 36%,...

Monomethyl fumarate is an active metabolite of the immune modulator dimethyl fumarate (Cay-14714) that is rapidly formed from dimethyl fumarate by hydrolysis. It is an agonist of the hydroxycarboxylic acid 2 (HCA2) receptor/GPR109A with an EC50 value of 9.4 µM for inducing calcium accumulation in CHO cells...

The G protein-coupled receptors GPR109A and GPR109B are recognized to be receptors for hydroxy-carboxylic acid (HCA) metabolites, are abundant in adipocytes, and are relevant to atherosclerosis and dyslipidemia. IPBT-5CA is a selective agonist of GPR109B (HCA3, EC50 = 400 nM). It displays no activity at GPR109A...

HCAR2, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. HCAR2 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HCAR2 contains seven transmembrane domains. Protein function: Acts as a high affinity receptor for both...

HCAR2, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. HCAR2 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HCAR2 contains seven transmembrane domains. Protein function: Acts as a high affinity receptor for both...

LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 µM in a radioligand binding assay). It stimulates [35S]-GTPgammaS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 µM, respectively). In vivo, LUF6283 (400 mg/kg...

D-Kynurenine is an antagonist of hydroxycarboxylic acid receptor 3 HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan. It increases levels of intracellular calcium and decreases forskolin-stimulated production of cAMP in CHO cells expressing human HCA3/GPR109B when used at...

MK-1903 is an agonist of hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A). It reduces forskolin-induced cAMP production in a homogenous time-resolved fluorescence (HTRF) assay using CHO cells expressing the human receptor (EC50 = 12.9 nM). MK-1903 is selective...

Protein function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)- protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses...

Acifran is a niacin receptor agonist. It binds to hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A) and niacin receptor 1, with an IC50 value of 1.12 µM, as well as induces ERK1/2 phosphorylation in CHO-K1 cells expressing HCA2 or HCA3, also known as GPR109B and...

Myristyl nicotinate is a prodrug form of the hydroxycarboxylic acid receptor 2 (HCA2) antagonist nicotinic acid (Cay-37416). Formulations containing myristyl nicotinate have been used in lotions for the treatment of epithelial photodamage.Formal Name: 3-pyridinecarboxylic acid, tetradecyl ester. CAS Number:...