- Search results for K08402
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37 products were found matching "K08402"!
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Item number: ELK-ELK4567.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GPR109B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GPR109B....
Keywords: | HCAR3, GPR109B, Niacin receptor 2, Nicotinic acid receptor 2, G-protein coupled receptor HM74, G-protein coupled receptor... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay37714-1
Myristyl nicotinate is a prodrug form of the hydroxycarboxylic acid receptor 2 (HCA2) antagonist nicotinic acid (Cay-37416). Formulations containing myristyl nicotinate have been used in lotions for the treatment of epithelial photodamage.Formal Name: 3-pyridinecarboxylic acid, tetradecyl ester. CAS Number:...
Keywords: | Tetradecyl Nicotinate, Tetradecyl Pyridine-3-carboxylate, 3-pyridinecarboxylic acid, tetradecyl ester |
Application: | Nicotinic acid prodrug form |
CAS | 273203-62-6 |
MW: | 319.5 D |
From 53.00€
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Item number: Cay27813-10
Monomethyl fumarate is an active metabolite of the immune modulator dimethyl fumarate (Cay-14714) that is rapidly formed from dimethyl fumarate by hydrolysis. It is an agonist of the hydroxycarboxylic acid 2 (HCA2) receptor/GPR109A with an EC50 value of 9.4 µM for inducing calcium accumulation in CHO cells...
Keywords: | Fumaric Acid monomethyl ester, 2E-butenedioic acid, 1-methyl ester |
Application: | HCAR2 (GPR109A) agonist |
CAS | 2756-87-8 |
MW: | 130.1 D |
From 84.00€
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Item number: Cay24609-5
3-hydroxy Octanoic acid is a hydroxylated fatty acid that has been found in LPS from P. aeruginosa and the methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by P. oleovorans. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils which endogenously...
Keywords: | 3-hydroxy Caprylic Acid, beta-hydroxy Octanoic Acid, 3-hydroxy-octanoic acid |
Application: | Hydroxylated fatty acid, GPR109B agonist |
CAS | 14292-27-4 |
MW: | 160.2 D |
From 77.00€
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-15 %
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Item number: ABE-11-8114-100
Protein function: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect...
Keywords: | Anti-HCAR3, Anti-GPR109B, Anti-Niacin receptor 2, Anti-Nicotinic acid receptor 2, Anti-G-protein coupled receptor 109B,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human |
134.00€
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From 113.90€
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Item number: Cay15223-1
The G protein-coupled receptors GPR109A and GPR109B are recognized to be receptors for hydroxy-carboxylic acid (HCA) metabolites, are abundant in adipocytes, and are relevant to atherosclerosis and dyslipidemia. IPBT-5CA is a selective agonist of GPR109B (HCA3, EC50 = 400 nM). It displays no activity at GPR109A...
Keywords: | IBC-293, 1-(1-methylethyl)-1H-benzotriazole-5-carboxylic acid |
Application: | GPR109B agonist |
CAS | 306935-41-1 |
MW: | 205.2 D |
From 43.00€
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Item number: E-AB-16467.120
HCAR2, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. HCAR2 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HCAR2 contains seven transmembrane domains. Protein function: Acts as a high affinity receptor for both...
Keywords: | Anti-HCAR2, Anti-GPR109A, Anti-Niacin receptor 1, Anti-Nicotinic acid receptor, Anti-G-protein coupled receptor 109A,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 71.00€
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Item number: E-AB-13276.120
HCAR2, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. HCAR2 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HCAR2 contains seven transmembrane domains. Protein function: Acts as a high affinity receptor for both...
Keywords: | Anti-HCAR2, Anti-GPR109A, Anti-Niacin receptor 1, Anti-Nicotinic acid receptor, Anti-G-protein coupled receptor 109A,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 71.00€
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Item number: Cay15423-1
LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 µM in a radioligand binding assay). It stimulates [35S]-GTPgammaS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 µM, respectively). In vivo, LUF6283 (400 mg/kg...
Keywords: | 5-butyl-1H-pyrazole-3-carboxylic acid |
Application: | GPR109A partial agonist |
CAS | 92933-48-7 |
MW: | 168.2 D |
From 43.00€
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Item number: Cay28254-100
D-Kynurenine is an antagonist of hydroxycarboxylic acid receptor 3 HCA3/GPR109B (EC50 = 2.61 µM in a luciferase reporter assay) and a metabolite of D-tryptophan. It increases levels of intracellular calcium and decreases forskolin-stimulated production of cAMP in CHO cells expressing human HCA3/GPR109B when used at...
Keywords: | alphaR,2-diamino-gamma-oxo-benzenebutanoic acid |
Application: | HCAR3/GPR109B antagonist |
CAS | 13441-51-5 |
MW: | 208.2 D |
From 189.00€
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Item number: Cay34304-1
MK-1903 is an agonist of hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A). It reduces forskolin-induced cAMP production in a homogenous time-resolved fluorescence (HTRF) assay using CHO cells expressing the human receptor (EC50 = 12.9 nM). MK-1903 is selective...
Keywords: | 4,4aR,5,5aR-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid |
Application: | HCA2 receptor agonist |
CAS | 1268882-43-4 |
MW: | 164.2 D |
From 50.00€
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Item number: G-CAB15611.100
WB 1:500 - 1:2000, IF 1:50 - 1:200. Protein function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological...
Keywords: | Anti-HCAR2, Anti-GPR109A, Anti-Niacin receptor 1, Anti-Nicotinic acid receptor, Anti-G-protein coupled receptor 109A,... |
Application: | WB, IF |
Host: | Rabbit |
Species reactivity: | human, rat |
From 352.00€
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