IPBT-5CA

The G protein-coupled receptors GPR109A and GPR109B are recognized to be receptors for hydroxy-carboxylic acid (HCA) metabolites, are abundant in adipocytes, and are relevant to atherosclerosis and dyslipidemia. IPBT-5CA is a selective agonist of GPR109B (HCA3, EC50 = 400 nM). It displays no activity at GPR109A (HCA2). IBC-293 inhibits forskolin-stimulated cAMP release in Chinese hamster ovary cells stably expressing GPR109B (EC50 = 54 nM) but not in cells expressing GPR109A. This is accompanied by a rapid and transient increase in intracellular calcium and activation of ERK1/2 through a pertussis toxin-sensitive Gi signaling pathway.Formal Name: 1-(1-methylethyl)-1H-benzotriazole-5-carboxylic acid. CAS Number: 306935-41-1. Synonyms: IBC-293. Molecular Formula: C10H11N3O2. Formula Weight: 205.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 222, 273 nm. SMILES: OC(C1=CC=C(N(C(C)C)N=N2)C2=C1)=O. InChi Code: InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15). InChi Key: RUTVRAJKELSHCC-UHFFFAOYSA-N.