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3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human THRa. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human THRa. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat THRa. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat THRa. Next,...

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite. It binds to thyroid hormone receptor alpha1 (TRalpha1), TRbeta1, and TRbeta2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays). 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism...

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 µg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Cay-22917) from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS)...

Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRalpha and TRbeta (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRalpha in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor...

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including...

Protein function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. [The UniProt Consortium]

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRalpha. INDIGO's reporter cells include the luciferase reporter gene...

INDIGO's panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A3) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRalpha and TRbeta. INDIGO's TR reporter cells include the luciferase reporter gene functionally...

Anti-Thyroid Hormone Receptor alpha 2 Monoclonal Antibody is directed against human thyroid hormone receptor alpha 2 protein. Thyroid Hormone Receptor alpha 2 antibodies are puriifed by Protein G chromatography. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, mouse...