L-Thyroxine

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 µg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone (Cay-22917) from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.Formal Name: O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine. CAS Number: 51-48-9. Synonyms: Levothyroxine, L-T4, NSC 36397. Molecular Formula: C15H11I4NO4. Formula Weight: 776.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.14 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.50 mg/ml. lambdamax: 212, 225, 292 nm. SMILES: OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1I. InChi Code: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1. InChi Key: XUIIKFGFIJCVMT-LBPRGKRZSA-N.