Altretamine-d18

Altretamine-d18 is intended for use as an internal standard for the quantification of altretamine (Cay-23662) by GC- or LC-MS. Altretamine is an anticancer agent. It induces cytotoxicity in an ovarian cancer cell line when used at a concentration of 10 µg/ml. Altretamine (0. mM) inhibits glutathione peroxidase 4 (GPX4) and induces accumulation of lipid-reactive oxygen species (ROS) in U-2932 cells without depleting glutathione (GSH) levels, suggesting it is a class II ferroptosis-inducing compound (FIN). In vivo, altretamine (150 mg/kg) reduces tumor growth in an M5076 murine sarcoma model. Formulations containing altretamine have been used in the treatment of ovarian cancer. Formal Name: N,N,N',N',N'',N''-hexa(methyl-d3)-1,3,5-triazine-2,4,6-triamine. CAS Number: 65886-69-3. Synonyms: Hexamethylmelamine-d18 HMM-d18 2,4,6-Tris(dimethylamino)-1,3,5-triazine-d18. Molecular Formula: C9D18N6. Formula Weight: 228.4. Purity: >99% deuterated forms d1-d18. Formulation (Request formulation change): A neat solid. Solubility: Chloroform: Soluble Methanol: Slightly soluble. SMILES: [2H]C([2H])([2H])N(C([2H])([2H])[2H])C1=NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N1. InChi Code: InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3/i1D3,2D3,3D3,4D3,5D3,6D3. InChi Key: UUVWYPNAQBNQJQ-NBDUPMGQSA-N. Storage: 4°C. Stability: > 2 years.