SR 3306

SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively). It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or 6-OHDA-induced neurodegeneration of dopaminergic neurons in the mouse substantia nigra pars compacta. SR 3306 (10 mg/kg) decreases D-amphetamine-induced circling in rats in a 6-OHDA model of Parkinson's disease. It also enhances leptin-induced STAT3 activation in the hypothalamus, reduces food intake, decreases body weight in diet-induced obese (DIO) mice when administered at a dose of 30 mg/kg.. SMILES: CC1=CC=C(C=N1)C(N=C2)=NN2C(C=C3)=CC=C3NC4=NC=CC(C5=CC(N6CCOCC6)=CC=C5)=N4. InChi Code: InChI=1S/C28H26N8O/c1-20-5-6-22(18-30-20)27-31-19-36(34-27)24-9-7-23(8-10-24)32-28-29-12-11-26(33-28)21-3-2-4-25(17-21)35-13-15-37-16-14-35/h2-12,17-19H,13-16H2,1H3,(H,29,32,33). InChi Key: QDMXVKKPYBGIAS-UHFFFAOYSA-N