56 products were found matching "K04160"!

CJ-033466 is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4. It induces cAMP accumulation in HEK293 cells expressing human 5-HT4D receptors and relaxation of rat tunica muscularis mucosae strips (EC50s = 0. and 1. nM, respectively). CJ-033466 selectively binds to 5-HT4D over 5-HT1A, 5-HT1B, 5-HT1D,...

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and alpha1- and alpha2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic...

Cisapride is an agonist of serotonin (5-HT) receptor subtype 5-HT4 (IC50 = 0.483 µM in COS-7 cells expressing the human receptor). It induces relaxation of precontracted isolated rat esophageal thoracic muscularis mucosae preparations (EC50 = 102.33 nM). Cisapride (0.5 mg/kg) increases the rate of gastric emptying...

Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM). As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, in both healthy and diseased gastrointestinal tracts. However, it lacks...

Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine...

The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1.{34073, 34070} In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production. In several animal models, low...

GR113808 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT4. It binds to 5-HT4 receptors with an IC50 value of 0.4 nM in COS-7 cells expressing the human recombinant receptor and in guinea pig striatal membranes (IC50 = 0.5 nM). GR113808 is selective for 5-HT4 receptors over 5-HT1 receptors (Kis = >10...

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36,...

Cisapride-d6 is intended for use as an internal standard for the quantification of cisapride (Cay-21657) by GC- or LC-MS. Cisapride is an agonist of serotonin (5-HT) receptor subtype 5-HT4 (IC50 = 0.483 µM in COS-7 cells expressing the human receptor). It induces relaxation of precontracted isolated rat esophageal...

BIMU 8 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69 nM). It also binds 5-HT3 receptors (Ki = 0.36 nM). It stimulates cAMP formation in primary mouse embryonic colliculi neurons with an EC50 value of 72 nM. BIMU 8 (30, 40, and 60 nmol/animal, i.c.v.) induces acetylcholine release in the rat...

Protein function: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. [The UniProt Consortium] Buffer: 40%...

Des-4-fluorobenzyl Mosapride is the primary metabolite of mosapride. Mosapride is a gastroprokinetic agent that enhances upper GI motility by activating serotonin receptor 4 (5-HT4, EC50 = 74.2 nM, in guinea pig ileal longitudinal muscle myenteric plexus). Mosapride increases canine, equine, and guinea pig colonic...