RS 67333 (hydrochloride)

RS 67333 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4. It selectively binds to 5-HT4 (Ki = 2 nM) over 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = 398, 501, 794, and 398 nM, respectively), as well as alpha- and beta-adrenergic and muscarinic receptors (Kis = >200 nM for all). It also binds to sigma1- and sigma2-receptors (Kis = 1 and 10 nM, respectively). RS 67333 induces relaxation of carbachol-precontracted rat esophageal muscularis mucosae preparations (EC50 = 2 nM) and induces tachycardia in anesthetized micropigs at 4.9 µg/kg. It reverses scopolamine-induced memory deficits in mice in the Y-maze test when administered at a dose of 1 mg/kg.. SMILES: O=C(CCC1CCN(CC1)CCCC)C2=C(OC)C=C(N)C(Cl)=C2.Cl. InChi Code: InChI=1S/C19H29ClN2O2.ClH/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2,/h12-14H,3-11,21H2,1-2H3,1H. InChi Key: XVBGLZNYWUUAFF-UHFFFAOYSA-N