TFLLR-NH2 (trifluoroacetate salt)

TFLLR-NH2 is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 µM). In vivo, TFLLR-NH2 (3 µmol/kg) stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type, but not PAR1-/-, mice. It also reduces carrageenan-induced hyperalgesia in rats.Formal Name: (S)-2-((S)-2-((2S,3R)-2-amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide, trifluoroacetate salt. Molecular Formula: C31H53N9O6 . XCF3COOH. Formula Weight: 647.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: NC(NCCC[C@@H](C(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC1=CC=CC=C1)=O)=O)CC(C)C)=O)=N.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41,3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36),(H,6,7)/t19-,21+,22+,23+,24+,25+,/m1./s1. InChi Key: QVNWOGSDGQDGHP-MKVNCOEFSA-N.