161 products were found matching "K00901"!

In 1X PBS, pH 7.4, with 0.09% sodium azide. DGKZ belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Protein function: Diacylglycerol kinase that converts diacylglycerol/DAG...

BMS 502 is an inhibitor of diacylglycerol kinase alpha (DGK-alpha), DGK-zeta, and DGK-iota (IC50s = 0.0046, 0.0021, and 0.0026 µM, respectively). It is selective for these DGKs over DGK-beta, DGK-gamma, and DGK-kappa (IC50s = 1, 0.68, and 4.6 µM, respectively). BMS 502 increases levels of IFN-gamma and...

Dioctanoyl glycol is a diacylglycerol kinase (DGK) inhibitor (Ki = 58 µM). It reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets when used at concentrations of 30, 100, and 500 µM.Formal Name: octanoic acid, 1,1'-(1,2-ethanediyl) ester. CAS Number: 627-86-1. Synonyms:...

Diacylglycerol (DAG) kinases (DGKs) phosphorylate DAG to give phosphatidic acid (PA), reducing signaling through DAG and increasing signaling through PA. R-59-022 is an inhibitor of DGK (IC50 = 2.8 µM). This results in increased DAG-dependent PKC activity and potentiates aggregation of thrombin-stimulated platelets....

R-59-949 is an inhibitor of diacylglycerol kinase alpha (DGK-alpha) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-alpha inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of...

Protein function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. [The UniProt Consortium]

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK, Ki = 3.1 µM) and diacylglycerol acyltransferase (DGAT, IC50 = 5.6 µM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 µM....

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding...

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase)...

Protein function: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. [The UniProt Consortium]

Protein function: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. [The UniProt Consortium]

Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed...